ID   Ecad-231-7
AC   CVCL_A9BP
SY   Ecad231-7
DR   cancercelllines; CVCL_A9BP
DR   CCRID; 1101HUM-PUMC000398
DR   Wikidata; Q108820180
RX   PubMed=21215101;
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1748; CDH1.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C5214; Breast adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0062 ! MDA-MB-231
SX   Female
AG   51Y
CA   Cancer cell line
DT   Created: 23-09-21; Last updated: 14-08-25; Version: 9
//
RX   PubMed=21215101; DOI=10.3760/cma.j.issn.0529-5807.2010.12.011;
RA   Yang, Li-Juan
RA   Liu, Yu-Qin
RA   Gu, Bei
RA   Bian, Xiao-Cui
RA   Feng, Hai-Liang
RA   Yang, Zhen-Li
RA   Liu, Yan-Yan
RT   "Effect of forced E-cadherin expression on adhesion and proliferation
RT   of human breast carcinoma cells.";
RL   Zhonghua Bing Li Xue Za Zhi 39:842-847(2010).
//