Cellosaurus cell line A549-hACE2 [BEI resources] (CVCL

Cellosaurus A549-hACE2 [BEI resources] (CVCL_A7UV)

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Cell line name

A549-hACE2 [BEI resources]

Accession

CVCL_A7UV

Resource Identification Initiative

To cite this cell line use: A549-hACE2 [BEI resources] (RRID:CVCL_A7UV)

Comments

Group: SARS-CoV-2 research cell line.
From: Baric, Ralph Steven; Department of Epidemiology, University of North Carolina at Chapel Hill; Chapel Hill; USA.
Population: Caucasian.
Characteristics: Expresses ACE2 under the control of the EF1a promoter (BEI_Resources=NR-53821).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:13557; ACE2.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.

Sequence variations

Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).

Disease

Lung adenocarcinoma (NCIt: C3512)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_0023 (A-549)
Children:

CVCL_D1JI (A549-AC)

Sex of cell

Male

Age at sampling

58Y