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Cellosaurus HCC4006-OsiR (CVCL_A7EW)

[Text version]
Cell line name HCC4006-OsiR
Accession CVCL_A7EW
Resource Identification Initiative To cite this cell line use: HCC4006-OsiR (RRID:CVCL_A7EW)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:90943; Osimertinib (AZD9291).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Leu747_Glu749del (c.2239_2247delTAAGAGAA); ClinVar=VCV000177765; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr205His (c.613T>C); ClinVar=VCV000376685; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1269 (HCC4006)
Sex of cell Male
Age at sampling >50Y
Category Cancer cell line
Publications

PubMed=32928921; DOI=10.1158/0008-5472.CAN-20-1634; PMCID=PMC11106563
Sun Y.-T., Meyers B.A., Czako B., Leonard P., Mseeh F., Harris A.L., Wu Q., Johnson S., Parker C.A., Cross J.B., Di Francesco M.E., Bivona B.J., Bristow C.A., Burke J.P., Carrillo C.C., Carroll C.L., Chang Q., Feng N.-P., Gao G., Gera S., Giuliani V., Huang J.K., Jiang Y.-Y., Kang Z.-J., Kovacs J.J., Liu C.-Y., Lopez A.M., Ma X.-Y., Mandal P.K., McAfoos T.J., Miller M.A., Mullinax R.A., Peoples M., Ramamoorthy V., Seth S., Spencer N.D., Suzuki E., Williams C.C., Yu S.S., Zuniga A.M., Draetta G.F., Marszalek J.R., Heffernan T.P., Kohl N.E., Jones P.
Allosteric SHP2 inhibitor, IACS-13909, overcomes EGFR-dependent and EGFR-independent resistance mechanisms toward osimertinib.
Cancer Res. 80:4840-4853(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A7EW
Encyclopedic resources Wikidata; Q107115246
Entry history
Entry creation20-May-2021
Last entry update05-Oct-2023
Version number6