ID   HCC4006-OsiR
AC   CVCL_A7EW
DR   cancercelllines; CVCL_A7EW
DR   Wikidata; Q107115246
RX   PubMed=32928921;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_90943; Osimertinib (AZD9291).
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Leu747_Glu749del (c.2239_2247delTAAGAGAA); ClinVar=VCV000177765; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr205His (c.613T>C); ClinVar=VCV000376685; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
CC   Cell type: Epithelial cell; CL=CL_0000066.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1269 ! HCC4006
SX   Male
AG   >50Y
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 14-08-25; Version: 8
//
RX   PubMed=32928921; DOI=10.1158/0008-5472.CAN-20-1634; PMCID=PMC11106563;
RA   Sun, Yu-Ting
RA   Meyers, Brooke A.
RA   Czako, Barbara
RA   Leonard, Paul
RA   Mseeh, Faika
RA   Harris, Angela L.
RA   Wu, Qi
RA   Johnson, Sarah
RA   Parker, Connor A.
RA   Cross, Jason B.
RA   Di Francesco, Maria Emilia
RA   Bivona, Benjamin J.
RA   Bristow, Christopher A.
RA   Burke, Jason P.
RA   Carrillo, Caroline C.
RA   Carroll, Christopher L.
RA   Chang, Qing
RA   Feng, Ning-Ping
RA   Gao, Guang
RA   Gera, Sonal
RA   Giuliani, Virginia
RA   Huang, Justin K.
RA   Jiang, Yong-Ying
RA   Kang, Zhi-Jun
RA   Kovacs, Jeffrey J.
RA   Liu, Chiu-Yi
RA   Lopez, Anastasia M.
RA   Ma, Xiao-Yan
RA   Mandal, Pijus K.
RA   McAfoos, Timothy J.
RA   Miller, Meredith A.
RA   Mullinax, Robert A.
RA   Peoples, Michael
RA   Ramamoorthy, Vandhana
RA   Seth, Sahil
RA   Spencer, Nakia D.
RA   Suzuki, Erika
RA   Williams, Christopher C.
RA   Yu, Simon S.
RA   Zuniga, Andy M.
RA   Draetta, Giulio F.
RA   Marszalek, Joseph R.
RA   Heffernan, Timothy P.
RA   Kohl, Nancy E.
RA   Jones, Philip
RT   "Allosteric SHP2 inhibitor, IACS-13909, overcomes EGFR-dependent and
RT   EGFR-independent resistance mechanisms toward osimertinib.";
RL   Cancer Res. 80:4840-4853(2020).
//