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Cellosaurus PC-7/CPT (CVCL_A787)

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Cell line name PC-7/CPT
Accession CVCL_A787
Resource Identification Initiative To cite this cell line use: PC-7/CPT (RRID:CVCL_A787)
Comments Population: Japanese.
Doubling time: 45.8 hours (PubMed=2168285).
Selected for resistance to: ChEBI; CHEBI_80630; Irinotecan (Camptothecin-11; CPT-11).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Gly719Ser (c.2155G>A); ClinVar=VCV000016612; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11986; TOP1; Simple; p.Thr729Ala (c.2185G>A); Zygosity=Unspecified (PubMed=1332703).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A786 (PC-7)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=2168285
Fumihiko Kanzawa, Yoshikazu Sugimoto, Koichi Minato, Kazuo Kasahara, Masami Bungo, Kazuhiko Nakagawa, Yasuhiro Fujiwara, Leroy Fong Liu, Nagahiro Saijo;
Establishment of a camptothecin analogue (CPT-11)-resistant cell line of human non-small cell lung cancer: characterization and mechanism of resistance.
Cancer Res. 50:5919-5924(1990)

PubMed=1332703; DOI=10.1016/0006-291X(92)91094-7
Naohiro Kubota, Fumihiko Kanzawa, Kazuto Nishio, Yuichiro Takeda, Tohru Ohmori, Yasuhiro Fujiwara, Yoshiteru Terashima, Nagahiro Saijo;
Detection of topoisomerase I gene point mutation in CPT-11 resistant lung cancer cell line.
Biochem. Biophys. Res. Commun. 188:571-577(1992)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A787
Encyclopedic resources Wikidata; Q54938466
Entry history
Entry creation06-Jun-2012
Last entry update27-Nov-2025
Version number18