| Cell line name |
UKRV-Mel-21a |
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| Accession |
CVCL_A722 |
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| Resource Identification Initiative |
To cite this cell line use: UKRV-Mel-21a (RRID:CVCL_A722) |
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| Comments |
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029. |
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| Sequence variations |
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=23348503).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).
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| HLA typing |
Source: PubMed=15592718
| Class I | | HLA-A | A*02:01,23:01 | | HLA-B | B*44:02,44:03:01 | | HLA-C | C*04:01:01,05:01 | | Class II | | HLA-DP | DPB1*04:01 | | HLA-DQ | DQB1*03:01:01,02:01 | | HLA-DR | DRB1*11:01,07:01 |
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| Disease |
Melanoma (NCIt: C3224) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Sex of cell |
Male |
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| Age at sampling |
Age unspecified |
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| Category |
Cancer cell line |
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| STR profile |
Source(s): ESTDAB=ESTDAB-063
Markers:
Run an STR similarity search on this cell line |
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| Publications | PubMed=10594685; DOI=10.1046/j.1365-2567.1999.00902.x; PMCID=PMC2326956
Sun Y.-S., Moller P., Berking C., Schlupen E.-M., Volkenandt M., Schadendorf D.
In vivo selective expansion of a tumour-specific cytotoxic T-cell clone derived from peripheral blood of a melanoma patient after vaccination with gene-modified autologous tumour cells.
Immunology 98:535-540(1999) PubMed=15592718; DOI=10.1007/s00262-004-0561-5; PMCID=PMC11032966
Rodriguez T., Mendez R., Roberts C.H., Ruiz-Cabello Osuna F., Dodi I.A., Lopez-Nevot M.A., Paco L., Maleno I., Marsh S.G.E., Pawelec G., Garrido F.
High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity.
Cancer Immunol. Immunother. 54:141-148(2005) PubMed=23348503; DOI=10.1126/science.1230062
Horn S., Figl A., Rachakonda P.S., Fischer C., Sucker A., Gast A., Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R.
TERT promoter mutations in familial and sporadic melanoma.
Science 339:959-961(2013) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_A722
ESTDAB; ESTDAB-063
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| Anatomy/cell type resources |
BTO; BTO_0005348
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| Encyclopedic resources |
Wikidata; Q54990616
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| Polymorphism and mutation databases |
Cosmic; 1846715
Cosmic; 2686528
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| Entry history |
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| Entry creation | 06-Jun-2012 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 20 |
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