ID   UKRV-Mel-21a
AC   CVCL_A722
DR   BTO; BTO_0005348
DR   cancercelllines; CVCL_A722
DR   Cosmic; 1846715
DR   Cosmic; 2686528
DR   ESTDAB; ESTDAB-063
DR   Wikidata; Q54990616
RX   PubMed=10594685;
RX   PubMed=15592718;
RX   PubMed=23348503;
CC   HLA typing: A*02:01,23:01; B*44:02,44:03:01; C*04:01:01,05:01; DPB1*04:01; DQB1*03:01:01,02:01; DRB1*11:01,07:01 (PubMed=15592718).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=23348503).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
ST   Source(s): ESTDAB=ESTDAB-063
ST   Amelogenin: X,Y
ST   CSF1PO: 10
ST   D13S317: 13,14
ST   D3S1358: 14,17
ST   D5S818: 12
ST   D7S820: 10,11
ST   FGA: 22
ST   TH01: 9.3
ST   TPOX: 8,11
ST   vWA: 17,18
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 20
//
RX   PubMed=10594685; DOI=10.1046/j.1365-2567.1999.00902.x; PMCID=PMC2326956;
RA   Sun Y.-S., Moller P., Berking C., Schlupen E.-M., Volkenandt M.,
RA   Schadendorf D.;
RT   "In vivo selective expansion of a tumour-specific cytotoxic T-cell
RT   clone derived from peripheral blood of a melanoma patient after
RT   vaccination with gene-modified autologous tumour cells.";
RL   Immunology 98:535-540(1999).
//
RX   PubMed=15592718; DOI=10.1007/s00262-004-0561-5; PMCID=PMC11032966;
RA   Rodriguez T., Mendez R., Roberts C.H., Ruiz-Cabello Osuna F., Dodi I.A.,
RA   Lopez-Nevot M.A., Paco L., Maleno I., Marsh S.G.E., Pawelec G.,
RA   Garrido F.;
RT   "High frequency of homozygosity of the HLA region in melanoma cell
RT   lines reveals a pattern compatible with extensive loss of
RT   heterozygosity.";
RL   Cancer Immunol. Immunother. 54:141-148(2005).
//
RX   PubMed=23348503; DOI=10.1126/science.1230062;
RA   Horn S., Figl A., Rachakonda P.S., Fischer C., Sucker A., Gast A.,
RA   Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R.;
RT   "TERT promoter mutations in familial and sporadic melanoma.";
RL   Science 339:959-961(2013).
//