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Cellosaurus 182-D1106-362 (CVCL_A6LD)

[Text version]
Cell line name 182-D1106-362
Synonyms 175D10
Accession CVCL_A6LD
Resource Identification Initiative To cite this cell line use: 182-D1106-362 (RRID:CVCL_A6LD)
Comments Group: Patented cell line.
Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-2810.
Biotechnology: The monoclonal antibody produced by this hybridoma was used to prepare the humanized IMAB362 (claudiximab; zolbetuximab) therapeutic antibody.
Monoclonal antibody isotype: IgG1, kappa.
Monoclonal antibody target: UniProtKB; P56856; Human CLDN18 (isoform A2 = CLDN18.2).
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy Parent: CVCL_3412 (P3X63Ag8U.1)
Category Hybridoma

PubMed=19047087; DOI=10.1158/1078-0432.CCR-08-1547
Sahin U., Koslowski M., Dhaene K., Usener D., Brandenburg G., Seitz G., Huber C., Tureci O.
Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development.
Clin. Cancer Res. 14:7624-7634(2008)

Sahin U., Tureci O., Mitnacht-Kraus R., Woll S., Jacobs S., Heinz C.
Combination therapy involving antibodies against claudin 18.2 for treatment of cancer.
Patent number US10314890, 11-Jun-2019

Sahin U., Tureci O., Usener D., Fritz S., Uherek C., Brandenburg G., Geppert H.-G., Schroder A.K., Thiel P.
Monoclonal antibodies against claudin-18 for treatment of cancer.
Patent number US10738108, 11-Aug-2020

Encyclopedic resources Wikidata; Q107113149
Entry history
Entry creation20-May-2021
Last entry update30-Jan-2024
Version number5