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Cellosaurus WIL2 MTIr-107 (CVCL_A6HR)

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Cell line name WIL2 MTIr-107
Synonyms MTIr-107; MTIr mutant 107
Accession CVCL_A6HR
Resource Identification Initiative To cite this cell line use: WIL2 MTIr-107 (RRID:CVCL_A6HR)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_44081; 6-methylthioinosine (6-methylmercaptopurine riboside).
Transformant: ChEBI; CHEBI_23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; HGNC; HGNC:11272; SPTA1; Simple; p.Ser1163Ala (c.3487T>G); ClinVar=VCV000258929; Zygosity=Homozygous (from parent cell line).
Disease Hereditary spherocytosis (NCIt: C97074)
Hereditary spherocytosis (ORDO: Orphanet_822)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6544 (WIL2)
Children:
CVCL_A6HS (WIL2 MTI-TG)
Sex of cell Male
Age at sampling 5Y
Category Transformed cell line
Publications

PubMed=197600; DOI=10.1126/science.197600
Michael Steven Hershfield, Floyd F. Snyder, Jarvis Edwin Seegmiller;
Adenine and adenosine are toxic to human lymphoblast mutants defective in purine salvage enzymes.
Science 197:1284-1287(1977)

Cross-references
Encyclopedic resources Wikidata; Q107117459
Entry history
Entry creation20-May-2021
Last entry update10-Apr-2025
Version number6