ID   WIL2 MTIr-107
AC   CVCL_A6HR
SY   MTIr-107; MTIr mutant 107
DR   Wikidata; Q107117459
RX   PubMed=197600;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_44081; 6-methylthioinosine (6-methylmercaptopurine riboside).
CC   Sequence variation: Mutation; HGNC; HGNC:11272; SPTA1; Simple; p.Ser1163Ala (c.3487T>G); ClinVar=VCV000258929; Zygosity=Homozygous (from parent cell line).
CC   Transformant: ChEBI; CHEBI_23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C97074; Hereditary spherocytosis
DI   ORDO; Orphanet_822; Hereditary spherocytosis
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6544 ! WIL2
SX   Male
AG   5Y
CA   Transformed cell line
DT   Created: 20-05-21; Last updated: 10-04-25; Version: 6
//
RX   PubMed=197600; DOI=10.1126/science.197600;
RA   Hershfield M.S., Snyder F.F., Seegmiller J.E.;
RT   "Adenine and adenosine are toxic to human lymphoblast mutants
RT   defective in purine salvage enzymes.";
RL   Science 197:1284-1287(1977).
//