Cellosaurus logo
expasy logo

Cellosaurus SNK-6 (CVCL_A673)

[Text version]
Cell line name SNK-6
Synonyms SNK6
Accession CVCL_A673
Resource Identification Initiative To cite this cell line use: SNK-6 (RRID:CVCL_A673)
Comments Population: Japanese.
Characteristics: IL2 dependent.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Transcriptomics; Microarray.
Omics: Variations; CNV analysis.
Derived from site: In situ; Nose, nasal cavity; UBERON=UBERON_0001707.
Cell type: NK T-cell; CL=CL_0000814.
Sequence variations
  • Mutation; HGNC; HGNC:882; ATR; Unexplicit; Ex29-34del; Zygosity=Heterozygous (PubMed=16827800).
Disease Nasal type extranodal NK/T-cell lymphoma (NCIt: C4684)
Extranodal nasal NK/T cell lymphoma (ORDO: Orphanet_86879)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
Publications

PubMed=11157488; DOI=10.1182/blood.V97.3.708
Hiroshi Nagata, Akiyoshi Konno, Nobuhiro Kimura, Yu Zhang, Michiko Kimura, Ayako Demachi, Teruaki Sekine, Kohtaro Yamamoto, Norio Shimizu;
Characterization of novel natural killer (NK)-cell and gammadelta T-cell lines established from primary lesions of nasal T/NK-cell lymphomas associated with the Epstein-Barr virus.
Blood 97:708-713(2001)

PubMed=12780797; DOI=10.1046/j.1365-2141.2003.04359.x
Yu Zhang, Hiroshi Nagata, Tatsuro Ikeuchi, Hiroyuki Mukai, Michiko K. Oyoshi, Ayako Demachi, Tomohiro Morio, Hiroshi Wakiguchi, Nobuhiro Kimura, Norio Shimizu, Kohtaro Yamamoto;
Common cytological and cytogenetic features of Epstein-Barr virus (EBV)-positive natural killer (NK) cells and cell lines derived from patients with nasal T/NK-cell lymphomas, chronic active EBV infection and hydroa vacciniforme-like eruptions.
Br. J. Haematol. 121:805-814(2003)

PubMed=16827800; DOI=10.1111/j.1349-7006.2006.00226.x; PMCID=PMC11159954
Angen Liu, Tetsuya Takakuwa, Wen-Juan Luo, Shigeki Fujita, Katsuyuki Aozasa;
Alterations in ATR in nasal NK/T-cell lymphoma and chronic active Epstein-Barr virus infection.
Cancer Sci. 97:605-610(2006)

PubMed=19194464; DOI=10.1038/leu.2009.3
Javeed Iqbal, Can Kucuk, Ronald J. Deleeuw, Gopesh Srivastava, Wayne Tam, Hui-Min Geng, David L. Klinkebiel, Judith K. Christman, Kavita N. Patel, K. Cao, L. Shen ...Show all 18 authors... , Karen Dybkaer, Ivy F.L. Tsui, Hesham H. Ali, N. Shimizu, Wing Yan Au, Wan L. Lam, Wing-Chung Chan; Show fewer authors
Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies.
Leukemia 23:1139-1151(2009)

PubMed=21052088; DOI=10.1038/leu.2010.255
Javeed Iqbal, Dennis D. Weisenburger, Aparajita Chowdhury, Ming-Ying Tsai, Gopesh Srivastava, Timothy Charles Greiner, Can Kucuk, Karen E. Deffenbacher, Julie Marie Vose, L. Smith, Wing Yan Au ...Show all 22 authors... , Shigeo Nakamura, Masao Seto, Jan Delabie, Francoise Berger, Florence Loong, Young-Hyeh Ko, Ivy Sng, X. Liu, Thomas P. Loughran Jr., James Olen Armitage, Wing-Chung Chan; Show fewer authors
International Peripheral T-cell Lymphoma Project
Natural killer cell lymphoma shares strikingly similar molecular features with a group of non-hepatosplenic gammadelta T-cell lymphoma and is highly sensitive to a novel aurora kinase A inhibitor in vitro.
Leukemia 25:348-358(2011)

PubMed=22102884; DOI=10.1371/journal.pone.0027271; PMCID=PMC3213120
Rajesh Ramakrishnan, Hart Donahue, David Garcia, Jie Tan, Norio Shimizu, Andrew P. Rice, Paul D. Ling;
Epstein-Barr virus BART9 miRNA modulates LMP1 levels and affects growth rate of nasal NK T cell lymphomas.
PLoS ONE 6:e27271.1-e27271.12(2011)

PubMed=25586472; DOI=10.1038/ncomms7025; PMCID=PMC7743911
Can Kucuk, Bei Jiang, Xiao-Zhou Hu, Wen-Yan Zhang, John K.C. Chan, Wen-Ming Xiao, Nathan Lack, Can Alkan, John C. Williams, Kendra N. Avery, Pynar Kavak ...Show all 28 authors... , Anna Scuto, Emel Sen, Philippe Gaulard, Louis Michael Staudt, Javeed Iqbal, Wei-Wei Zhang, Adam Cornish, Qiang Gong, Qun-Pei Yang, Hong Sun, Francesco Annibale d'Amore, Sirpa Leppa, Wei-Ping Liu, Kai Fu, Laurence de Leval, Timothy W. McKeithan, Wing-Chung Chan; Show fewer authors
Activating mutations of STAT5B and STAT3 in lymphomas derived from gammadelta-T or NK cells.
Nat. Commun. 6:6025.1-6025.12(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A673
Encyclopedic resources Wikidata; Q54955067
Gene expression databases GEO; GSM472006
GEO; GSM3021083
Polymorphism and mutation databases Cosmic; 1534873
Cosmic; 1542074
Cosmic; 2025327
Cosmic; 2390118
Cosmic; 2785206
Progenetix; CVCL_A673
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number22