ID   SNK-6
AC   CVCL_A673
SY   SNK6
DR   cancercelllines; CVCL_A673
DR   Cosmic; 1534873
DR   Cosmic; 1542074
DR   Cosmic; 2025327
DR   Cosmic; 2390118
DR   Cosmic; 2785206
DR   GEO; GSM472006
DR   GEO; GSM3021083
DR   Progenetix; CVCL_A673
DR   Wikidata; Q54955067
RX   PubMed=11157488;
RX   PubMed=12780797;
RX   PubMed=16827800;
RX   PubMed=19194464;
RX   PubMed=21052088;
RX   PubMed=22102884;
RX   PubMed=25586472;
CC   Population: Japanese.
CC   Characteristics: IL2 dependent.
CC   Sequence variation: Mutation; HGNC; HGNC:882; ATR; Unexplicit; Ex29-34del; Zygosity=Heterozygous (PubMed=16827800).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; CNV analysis.
CC   Derived from site: In situ; Nose, nasal cavity; UBERON=UBERON_0001707.
CC   Cell type: NK T-cell; CL=CL_0000814.
DI   NCIt; C4684; Nasal type extranodal NK/T-cell lymphoma
DI   ORDO; Orphanet_86879; Extranodal nasal NK/T cell lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   62Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 22
//
RX   PubMed=22102884; DOI=10.1371/journal.pone.0027271; PMCID=PMC3213120;
RA   Ramakrishnan, Rajesh
RA   Donahue, Hart
RA   Garcia, David
RA   Tan, Jie
RA   Shimizu, Norio
RA   Rice, Andrew P.
RA   Ling, Paul D.
RT   "Epstein-Barr virus BART9 miRNA modulates LMP1 levels and affects
RT   growth rate of nasal NK T cell lymphomas.";
RL   PLoS ONE 6:e27271.1-e27271.12(2011).
//
RX   PubMed=21052088; DOI=10.1038/leu.2010.255;
RA   Iqbal, Javeed
RA   Weisenburger, Dennis D.
RA   Chowdhury, Aparajita
RA   Tsai, Ming-Ying
RA   Srivastava, Gopesh
RA   Greiner, Timothy Charles
RA   Kucuk, Can
RA   Deffenbacher, Karen E.
RA   Vose, Julie Marie
RA   Smith, Lynette
RA   Au, Wing Yan
RA   Nakamura, Shigeo
RA   Seto, Masao
RA   Delabie, Jan
RA   Berger, Francoise
RA   Loong, Florence
RA   Ko, Young-Hyeh
RA   Sng, Ivy
RA   Liu, Xin
RA   Loughran, Thomas P. Jr.
RA   Armitage, James Olen
RA   Chan, Wing-Chung
RG   International Peripheral T-cell Lymphoma Project;
RT   "Natural killer cell lymphoma shares strikingly similar molecular
RT   features with a group of non-hepatosplenic gammadelta T-cell lymphoma
RT   and is highly sensitive to a novel aurora kinase A inhibitor in
RT   vitro.";
RL   Leukemia 25:348-358(2011).
//
RX   PubMed=16827800; DOI=10.1111/j.1349-7006.2006.00226.x; PMCID=PMC11159954;
RA   Liu, Angen
RA   Takakuwa, Tetsuya
RA   Luo, Wen-Juan
RA   Fujita, Shigeki
RA   Aozasa, Katsuyuki
RT   "Alterations in ATR in nasal NK/T-cell lymphoma and chronic active
RT   Epstein-Barr virus infection.";
RL   Cancer Sci. 97:605-610(2006).
//
RX   PubMed=11157488; DOI=10.1182/blood.V97.3.708;
RA   Nagata, Hiroshi
RA   Konno, Akiyoshi
RA   Kimura, Nobuhiro
RA   Zhang, Yu
RA   Kimura, Michiko
RA   Demachi, Ayako
RA   Sekine, Teruaki
RA   Yamamoto, Kohtaro
RA   Shimizu, Norio
RT   "Characterization of novel natural killer (NK)-cell and gammadelta
RT   T-cell lines established from primary lesions of nasal T/NK-cell
RT   lymphomas associated with the Epstein-Barr virus.";
RL   Blood 97:708-713(2001).
//
RX   PubMed=25586472; DOI=10.1038/ncomms7025; PMCID=PMC7743911;
RA   Kucuk, Can
RA   Jiang, Bei
RA   Hu, Xiao-Zhou
RA   Zhang, Wen-Yan
RA   Chan, John K.C.
RA   Xiao, Wen-Ming
RA   Lack, Nathan
RA   Alkan, Can
RA   Williams, John C.
RA   Avery, Kendra N.
RA   Kavak, Pynar
RA   Scuto, Anna
RA   Sen, Emel
RA   Gaulard, Philippe
RA   Staudt, Louis Michael
RA   Iqbal, Javeed
RA   Zhang, Wei-Wei
RA   Cornish, Adam
RA   Gong, Qiang
RA   Yang, Qun-Pei
RA   Sun, Hong
RA   d'Amore, Francesco Annibale
RA   Leppa, Sirpa
RA   Liu, Wei-Ping
RA   Fu, Kai
RA   de Leval, Laurence
RA   McKeithan, Timothy W.
RA   Chan, Wing-Chung
RT   "Activating mutations of STAT5B and STAT3 in lymphomas derived from
RT   gammadelta-T or NK cells.";
RL   Nat. Commun. 6:6025.1-6025.12(2015).
//
RX   PubMed=12780797; DOI=10.1046/j.1365-2141.2003.04359.x;
RA   Zhang, Yu
RA   Nagata, Hiroshi
RA   Ikeuchi, Tatsuro
RA   Mukai, Hiroyuki
RA   Oyoshi, Michiko K.
RA   Demachi, Ayako
RA   Morio, Tomohiro
RA   Wakiguchi, Hiroshi
RA   Kimura, Nobuhiro
RA   Shimizu, Norio
RA   Yamamoto, Kohtaro
RT   "Common cytological and cytogenetic features of Epstein-Barr virus
RT   (EBV)-positive natural killer (NK) cells and cell lines derived from
RT   patients with nasal T/NK-cell lymphomas, chronic active EBV infection
RT   and hydroa vacciniforme-like eruptions.";
RL   Br. J. Haematol. 121:805-814(2003).
//
RX   PubMed=19194464; DOI=10.1038/leu.2009.3;
RA   Iqbal, Javeed
RA   Kucuk, Can
RA   Deleeuw, Ronald J.
RA   Srivastava, Gopesh
RA   Tam, Wayne
RA   Geng, Hui-Min
RA   Klinkebiel, David L.
RA   Christman, Judith K.
RA   Patel, Kavita N.
RA   Cao, Ka-Jia
RA   Shen, Li-Jun
RA   Dybkaer, Karen
RA   Tsui, Ivy F.L.
RA   Ali, Hesham H.
RA   Shimizu, Norio
RA   Au, Wing Yan
RA   Lam, Wan L.
RA   Chan, Wing-Chung
RT   "Genomic analyses reveal global functional alterations that promote
RT   tumor growth and novel tumor suppressor genes in natural killer-cell
RT   malignancies.";
RL   Leukemia 23:1139-1151(2009).
//