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Cellosaurus HU-3 (CVCL_A619)

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Cell line name HU-3
Accession CVCL_A619
Resource Identification Initiative To cite this cell line use: HU-3 (RRID:CVCL_A619)
Comments Characteristics: CSF2 dependent (PubMed=9406997).
Doubling time: 60 +- 11 hours (PubMed=9096695).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Disease Adult acute megakaryoblastic leukemia (NCIt: C7965)
Acute megakaryoblastic leukemia (ORDO: Orphanet_518)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_E9WZ (HU-3 clone D3)CVCL_E9X0 (HU-3 clone D7)CVCL_E9X1 (HU-3 clone E11)
CVCL_E9X2 (HU-3 clone E6)CVCL_E9X3 (HU-3 clone F5)CVCL_E9X4 (HU-3 clone G3)
CVCL_E9X5 (HU-3 clone G5)CVCL_E9X6 (HU-3 clone H7)CVCL_E9X7 (HU-3 clone H9)
CVCL_RM04 (HU-3/TPO)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=9096695; DOI=10.1038/sj.leu.2400621
Hans Gunther Drexler, Margarete Zaborski, Hilmar Quentmeier;
Thrombopoietin supports the continuous growth of cytokine-dependent human leukemia cell lines.
Leukemia 11:541-551(1997)

PubMed=9406997
Doris A. Morgan, Reiner Class, Gerald Soslau, Isadore Brodsky;
Cytokine-mediated erythroid maturation in megakaryoblastic human cell line HU-3.
Exp. Hematol. 25:1378-1385(1997)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Hilmar Quentmeier, Roderick A.F. MacLeod, Margarete Zaborski, Hans Gunther Drexler;
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

Cross-references
Encyclopedic resources Wikidata; Q54896687
Polymorphism and mutation databases Cosmic; 787436
Cosmic; 975255
Cosmic; 1012070
Cosmic; 1281318
Cosmic; 2306210
Entry history
Entry creation06-Jun-2012
Last entry update14-Aug-2025
Version number11