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Cellosaurus FET (CVCL_A604)

[Text version]
Cell line name FET
Synonyms HCT-FET; HCT FET
Accession CVCL_A604
Resource Identification Initiative To cite this cell line use: FET (RRID:CVCL_A604)
Comments Doubling time: 35.49 hours (PubMed=25944804).
Microsatellite instability: Stable (MSS) (PubMed=9000147; PubMed=25926053).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=25926053

Markers:
AmelogeninX
CSF1PO12
D5S81814
D7S8208,11
D13S31711
D16S53912
D21S1128,32.2
TH017
TPOX8
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=7329817
Michael G. Brattain, Diane E. Brattain, W. David Fine, F. Mahnaz Khaled, Michael E. Marks, Pamela M. Kimball, Laurie A. Arcolano, Bernice H. Danbury;
Initiation and characterization of cultures of human colonic carcinoma with different biological characteristics utilizing feeder layers of confluent fibroblasts.
Oncodev. Biol. Med. 2:355-366(1981)

PubMed=6437669; DOI=10.1007/BF00048384
Michael G. Brattain, Alan E. Levine, Subhas Chakrabarty, Lynn C. Yeoman, James K.V. Willson, Bing Long;
Heterogeneity of human colon carcinoma.
Cancer Metastasis Rev. 3:177-191(1984)

PubMed=2835152
Douglas Boyd, Germaine Florent, Paul Kim, Michael G. Brattain;
Determination of the levels of urokinase and its receptor in human colon carcinoma cell lines.
Cancer Res. 48:3112-3116(1988)

PubMed=3349466
Isabelle Chantret, Alain Barbat, Elisabeth Dussaulx, Michael G. Brattain, Alain Zweibaum;
Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: a survey of twenty cell lines.
Cancer Res. 48:1936-1942(1988)

PubMed=7761852; DOI=10.1126/science.7761852
Sanford David Markowitz, Jing Wang, Lois Lemmermann Myeroff, Ramon Parsons, Lu-Zhe Sun, James D. Lutterbaugh, Robert S. Fan, Elizabeth Zborowska, Kenneth Wayne Kinzler, Bert Vogelstein, Michael G. Brattain, James K.V. Willson;
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability.
Science 268:1336-1338(1995)

PubMed=8895552; DOI=10.1002/(SICI)1097-0215(19960927)68:1<126::AID-IJC22>3.0.CO;2-8
Laurent Suardet, Chuan Li, John Bertram Little;
Radio-induced modulation of transforming growth factor beta1 sensitivity in a p53 wild-type human colorectal-cancer cell line.
Int. J. Cancer 68:126-131(1996)

PubMed=9000147
Paul-Henri Cottu, Francoise Muzeau, Anne Estreicher, Jean-Francois Flejou, Richard D. Iggo, Gilles Thomas, Richard Hamelin;
Inverse correlation between RER+ status and p53 mutation in colorectal cancer cell lines.
Oncogene 13:2727-2730(1996)

PubMed=9000572
Jean-Marc Hoang, Paul-Henri Cottu, Benedicte Thuille, Remi J. Salmon, Gilles Thomas, Richard Hamelin;
BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines.
Cancer Res. 57:300-303(1997)

PubMed=11526487; DOI=10.1038/sj.onc.1204611
Jacqueline Gayet, Xiao-Ping Zhou, Alex Duval, Sandra Rolland, Jean-Marc Hoang, Paul-Henri Cottu, Richard Hamelin;
Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines.
Oncogene 20:5025-5032(2001)

PubMed=17363507; DOI=10.1158/1535-7163.MCT-06-0555
Jing Wang, Karen K. Kuropatwinski, Jennie Hauser, Michael R. Rossi, Yun-Fei Zhou, Alexis Conway, Julie L.C. Kan, Neil W. Gibson, James K.V. Willson, John Kenneth Cowell, Michael G. Brattain;
Colon carcinoma cells harboring PIK3CA mutations display resistance to growth factor deprivation induced apoptosis.
Mol. Cancer Ther. 6:1143-1150(2007)

PubMed=25926053; DOI=10.1038/ncomms8002
Enzo Medico, Mariangela Russo, Gabriele Picco, Carlotta Cancelliere, Emanuele Valtorta, Giorgio Corti, Michela Buscarino, Claudio Isella, Simona Lamba, Barbara Martinoglio, Silvio Veronese ...Show all 19 authors... , Salvatore Siena, Andrea Sartore-Bianchi, Marco Beccuti, Marcella Mottolese, Michael Linnebacher, Francesca Cordero, Federica Di Nicolantonio, Alberto Bardelli; Show fewer authors
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=25944804; DOI=10.1158/1078-0432.CCR-14-2457
Sarah Bazzocco, Higinio Dopeso, Fernando Carton-Garcia, Irati Macaya, Elena Andretta, Fiona Chionh, Paulo Rodrigues, Miriam Garrido, Hafid Alazzouzi, Rocio Nieto, Alex Sanchez ...Show all 15 authors... , Simo Schwartz Jr., Josipa Bilic, John M. Mariadason, Diego Arango; Show fewer authors
Highly expressed genes in rapidly proliferating tumor cells as new targets for colorectal cancer treatment.
Clin. Cancer Res. 21:3695-3704(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A604
ColonAtlas; FET
Encyclopedic resources Wikidata; Q54834763
Experimental variables resources EFO; EFO_0022636
Gene expression databases GEO; GSM1448154
Polymorphism and mutation databases Cosmic; 711265
Cosmic; 887232
Cosmic; 1131684
Cosmic; 2667880
IARC_TP53; 6476
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number25