ID   FET
AC   CVCL_A604
SY   HCT-FET; HCT FET
DR   cancercelllines; CVCL_A604
DR   ColonAtlas; FET
DR   Cosmic; 711265
DR   Cosmic; 887232
DR   Cosmic; 1131684
DR   Cosmic; 2667880
DR   GEO; GSM1448154
DR   IARC_TP53; 6476
DR   Wikidata; Q54834763
RX   PubMed=2835152;
RX   PubMed=3349466;
RX   PubMed=6437669;
RX   PubMed=7329817;
RX   PubMed=7761852;
RX   PubMed=8895552;
RX   PubMed=9000147;
RX   PubMed=9000572;
RX   PubMed=11526487;
RX   PubMed=17363507;
RX   PubMed=25926053;
RX   PubMed=25944804;
CC   Doubling time: 35.49 hours (PubMed=25944804).
CC   Microsatellite instability: Stable (MSS) (PubMed=9000147; PubMed=25926053).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Cys176Phe (c.527G>T); ClinVar=VCV000376569; Zygosity=Unspecified (PubMed=9000147).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
ST   Source(s): PubMed=25926053
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 11
ST   D16S539: 12
ST   D21S11: 28,32.2
ST   D5S818: 14
ST   D7S820: 8,11
ST   TH01: 7
ST   TPOX: 8
ST   vWA: 16,17
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 05-10-23; Version: 22
//
RX   PubMed=2835152;
RA   Boyd D., Florent G., Kim P., Brattain M.G.;
RT   "Determination of the levels of urokinase and its receptor in human
RT   colon carcinoma cell lines.";
RL   Cancer Res. 48:3112-3116(1988).
//
RX   PubMed=3349466;
RA   Chantret I., Barbat A., Dussaulx E., Brattain M.G., Zweibaum A.;
RT   "Epithelial polarity, villin expression, and enterocytic
RT   differentiation of cultured human colon carcinoma cells: a survey of
RT   twenty cell lines.";
RL   Cancer Res. 48:1936-1942(1988).
//
RX   PubMed=6437669; DOI=10.1007/BF00048384;
RA   Brattain M.G., Levine A.E., Chakrabarty S., Yeoman L.C.,
RA   Willson J.K.V., Long B.;
RT   "Heterogeneity of human colon carcinoma.";
RL   Cancer Metastasis Rev. 3:177-191(1984).
//
RX   PubMed=7329817;
RA   Brattain M.G., Brattain D.E., Fine W.D., Khaled F.M., Marks M.E.,
RA   Kimball P.M., Arcolano L.A., Danbury B.H.;
RT   "Initiation and characterization of cultures of human colonic
RT   carcinoma with different biological characteristics utilizing feeder
RT   layers of confluent fibroblasts.";
RL   Oncodev. Biol. Med. 2:355-366(1981).
//
RX   PubMed=7761852; DOI=10.1126/science.7761852;
RA   Markowitz S.D., Wang J., Myeroff L.L., Parsons R., Sun L.-Z.,
RA   Lutterbaugh J.D., Fan R.S., Zborowska E., Kinzler K.W., Vogelstein B.,
RA   Brattain M.G., Willson J.K.V.;
RT   "Inactivation of the type II TGF-beta receptor in colon cancer cells
RT   with microsatellite instability.";
RL   Science 268:1336-1338(1995).
//
RX   PubMed=8895552; DOI=10.1002/(SICI)1097-0215(19960927)68:1<126::AID-IJC22>3.0.CO;2-8;
RA   Suardet L., Li C., Little J.B.;
RT   "Radio-induced modulation of transforming growth factor beta1
RT   sensitivity in a p53 wild-type human colorectal-cancer cell line.";
RL   Int. J. Cancer 68:126-131(1996).
//
RX   PubMed=9000147;
RA   Cottu P.-H., Muzeau F., Estreicher A., Flejou J.-F., Iggo R.D.,
RA   Thomas G., Hamelin R.;
RT   "Inverse correlation between RER+ status and p53 mutation in
RT   colorectal cancer cell lines.";
RL   Oncogene 13:2727-2730(1996).
//
RX   PubMed=9000572;
RA   Hoang J.-M., Cottu P.-H., Thuille B., Salmon R.J., Thomas G.,
RA   Hamelin R.;
RT   "BAT-26, an indicator of the replication error phenotype in colorectal
RT   cancers and cell lines.";
RL   Cancer Res. 57:300-303(1997).
//
RX   PubMed=11526487; DOI=10.1038/sj.onc.1204611;
RA   Gayet J., Zhou X.-P., Duval A., Rolland S., Hoang J.-M., Cottu P.-H.,
RA   Hamelin R.;
RT   "Extensive characterization of genetic alterations in a series of
RT   human colorectal cancer cell lines.";
RL   Oncogene 20:5025-5032(2001).
//
RX   PubMed=17363507; DOI=10.1158/1535-7163.MCT-06-0555;
RA   Wang J., Kuropatwinski K., Hauser J., Rossi M.R., Zhou Y.-F., Conway A.,
RA   Kan J.L.C., Gibson N.W., Willson J.K.V., Cowell J.K., Brattain M.G.;
RT   "Colon carcinoma cells harboring PIK3CA mutations display resistance
RT   to growth factor deprivation induced apoptosis.";
RL   Mol. Cancer Ther. 6:1143-1150(2007).
//
RX   PubMed=25926053; DOI=10.1038/ncomms8002;
RA   Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G.,
RA   Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S.,
RA   Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M.,
RA   Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.;
RT   "The molecular landscape of colorectal cancer cell lines unveils
RT   clinically actionable kinase targets.";
RL   Nat. Commun. 6:7002.1-7002.10(2015).
//
RX   PubMed=25944804; DOI=10.1158/1078-0432.CCR-14-2457;
RA   Bazzocco S., Dopeso H., Carton-Garcia F., Macaya I., Andretta E.,
RA   Chionh F., Rodrigues P., Garrido M., Alazzouzi H., Nieto R.,
RA   Sanchez A., Schwartz S. Jr., Bilic J., Mariadason J.M., Arango D.;
RT   "Highly expressed genes in rapidly proliferating tumor cells as new
RT   targets for colorectal cancer treatment.";
RL   Clin. Cancer Res. 21:3695-3704(2015).
//