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Cellosaurus ARH-77 clone A5P3 (CVCL_A5YK)

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Cell line name ARH-77 clone A5P3
Synonyms ARH-77A5P3; A5P3
Accession CVCL_A5YK
Resource Identification Initiative To cite this cell line use: ARH-77 clone A5P3 (RRID:CVCL_A5YK)
Comments Problematic cell line: Misclassified. Parent cell line (ARH-77) was originally thought to be a myeloma cell line but is a B-lymphoblastoid cell line.
Population: Caucasian.
Genetic integration: Method=Transfection; Gene=MGI; MGI:1349162; Sdc1.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1072 (ARH-77)
Sex of cell Female
Age at sampling 33Y
Category Transformed cell line
Publications

PubMed=8051085; DOI=10.1016/S0021-9258(17)32120-8
Brian F. Liebersbach, Ralph D. Sanderson;
Expression of syndecan-1 inhibits cell invasion into type I collagen.
J. Biol. Chem. 269:20013-20019(1994)

PubMed=11001907; DOI=10.1182/blood.V96.7.2528
Magne Borset, Oyvind Hjertner, Shmuel Yaccoby, Joshua Epstein, Ralph D. Sanderson;
Syndecan-1 is targeted to the uropods of polarized myeloma cells where it promotes adhesion and sequesters heparin-binding proteins.
Blood 96:2528-2536(2000)

Cross-references
Encyclopedic resources Wikidata; Q107113379
Entry history
Entry creation20-May-2021
Last entry update14-Aug-2025
Version number8