Cellosaurus cell line imWilms6 (CVCL

Cellosaurus imWilms6 (CVCL_A5SQ)

[Text version]

Cell line name

imWilms6

Synonyms

IM-WT-6

Accession

CVCL_A5SQ

Resource Identification Initiative

To cite this cell line use: imWilms6 (RRID:CVCL_A5SQ)

Comments

Population: Caucasian.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.

Sequence variations

Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Homozygous (PubMed=33379206).
Mutation; HGNC; HGNC:12796; WT1; Simple; p.Arg390Ter (c.1168C>T) (p.Arg463Ter, c.1387C>T); ClinVar=VCV000003494; Zygosity=Homozygous (PubMed=33379206).

Disease

Kidney Wilms tumor (NCIt: C40407)
Nephroblastoma (ORDO: Orphanet_654)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_A5SI (Wilms6)

Sex of cell

Male

Age at sampling

1Y3M

Category

Conditionally immortalized cell line

STR profile

Source(s): PubMed=33379206

Markers:

Amelogenin	X,Y
CSF1PO	11,12
D3S1358	15,16
D5S818	8,9
D7S820	8,11
D8S1179	11,13
D13S317	8,11
D16S539	9,11
D18S51	12,16
D21S11	28,30
FGA	22,23
Penta D	11
Penta E	8,13
TH01	9
TPOX	11
vWA	16,18

Publications

PubMed=33379206; DOI=10.3390/cancers13010060; PMCID=PMC7801943
Brigitte Royer-Pokora, Maike Anna Busch, Sarah Tenbusch, Mathias Schmidt, Manfred Beier, Andrew D. Woods, Holger Thiele, Jaume Mora;
Comprehensive biology and genetics compendium of Wilms tumor cell lines with different WT1 mutations.
Cancers (Basel) 13:60.1-60.21(2021)

Cross-references

Encyclopedic resources

Wikidata; Q107115461

Entry history

Entry creation

20-May-2021

Last entry update

14-Aug-2025

Version number