Cellosaurus cell line CD#68T-13 iPSC (CVCL

Cellosaurus CD#68T-13 iPSC (CVCL_A5RU)

Cross-references
Cell line name	CD#68T-13 iPSC
Synonyms	CD68T-13 iPSC
Accession	CVCL_A5RU
Resource Identification Initiative	To cite this cell line use: CD#68T-13 iPSC (RRID:CVCL_A5RU)
Comments	Population: Jewish. Characteristics: Using TALEN a EF1a promoter-ASPA-T2A-CD19t construct was introduced in the AAVS1 safe harbor locus (PubMed=33304759). Genetic integration: Method=TALEN; Gene=HGNC; HGNC:756; ASPA. Genetic integration: Method=TALEN; Gene=HGNC; HGNC:1633; CD19 (Note=With p.Lys324_Arg556del = CD19t). Cell type: Fibroblast; CL=CL_0000057.
Sequence variations	Mutation; HGNC; HGNC:756; ASPA; Simple; p.Glu285Ala (c.854A>C); ClinVar=VCV000002605; Zygosity=Homozygous (PubMed=33304759).
Disease	Canavan disease (NCIt: C84611) Canavan disease (ORDO: Orphanet_141)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_A5RM (CD#68 iPSC)
Sex of cell	Male
Age at sampling	2Y
Category	Induced pluripotent stem cell
Publications	PubMed=33304759; DOI=10.1002/advs.202002155; PMCID=PMC7709977 Li-Zhao Feng, Jian-Fei Chao, E. Tian, Li Li, Peng Ye, Mi Zhang, Xian-Wei Chen, Qi Cui, Gui-Hua Sun, Tao Zhou, Gerardo Felix ...Show all 24 authors... , Yue Qin, Wen-Dong Li, Edward David Meza, Jeremy Klein, Lucy Y. Ghoda, Wei-Dong Hu, Yong-Lun Luo, Wei Dang, David Hsu, Joseph D. Gold, Steven A. Goldman, Reuben Karl Matalon, Yan-Hong Shi; Show fewer authors Cell-based therapy for Canavan disease using human iPSC-derived NPCs and OPCs. Adv. Sci. (Weinh.) 7:2002155.1-2002155.19(2020)
Encyclopedic resources	Wikidata; Q107114635
Entry history
Entry creation	20-May-2021
Last entry update	19-Dec-2024
Version number	7