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Cellosaurus A549-hACE2-TMPRSS2 (CVCL_A5KB)

[Text version]
Cell line name A549-hACE2-TMPRSS2
Accession CVCL_A5KB
Resource Identification Initiative To cite this cell line use: A549-hACE2-TMPRSS2 (RRID:CVCL_A5KB)
Comments Group: SARS-CoV-2 research cell line.
Population: Caucasian.
Virology: Highly susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) and/or spike-pseudotyped lentiviral particles (InvivoGen).
Transfected with: HGNC; 13557; ACE2.
Transfected with: HGNC; 11876; TMPRSS2.
Transfected with: UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A5KA (A549-hACE2 [Invivogen])
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Web pages https://www.invivogen.com/a549-ace2-tmprss2-cells
Cell line databases/resources cancercelllines; CVCL_A5KB
Encyclopedic resources Wikidata; Q107113337
Entry history
Entry creation20-May-2021
Last entry update05-Oct-2023
Version number7