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Cellosaurus SB-28-Ohlfest (CVCL_A5ED)

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Cell line name SB-28-Ohlfest
Synonyms SB-28; SB28
Accession CVCL_A5ED
Resource Identification Initiative To cite this cell line use: SB-28-Ohlfest (RRID:CVCL_A5ED)
Comments Characteristics: Glioma was induced by intraventricular transfection of pT2/C-Luc/PGKp-SB100 and Sleeping Beauty (SB)-flanked pT2/CAG-NRasV12 and pT2/shp53/mPDGF.
Doubling time: ~30 hours (DSMZ=ACC-880).
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Omics: Genomics; Whole exome sequencing.
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Disease Mouse glioblastoma (NCIt: C21938)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Age at sampling <1D
Category Cancer cell line
Publications

PubMed=24878890; DOI=10.1007/s00262-014-1561-8; PMCID=PMC4221287
Akemi Kosaka, Takayuki Ohkuri, Hideho Okada;
Combination of an agonistic anti-CD40 monoclonal antibody and the COX-2 inhibitor celecoxib induces anti-glioma effects by promotion of type-1 immunity in myeloid cells and T-cells.
Cancer Immunol. Immunother. 63:847-857(2014)

PubMed=30524896; DOI=10.1080/2162402X.2018.1501137; PMCID=PMC6279422
Vassilis Genoud, Eliana Marinari, Sergey Igorievich Nikolaev, John C. Castle, Valesca Bukur, Pierre-Yves Dietrich, Hideho Okada, Paul R. Walker;
Responsiveness to anti-PD-1 and anti-CTLA-4 immune checkpoint blockade in SB28 and GL261 mouse glioma models.
OncoImmunology 7:e1501137.1-e1501137.10(2018)

Cross-references
Cell line collections (Providers) DSMZ; ACC-880
Cell line databases/resources DSMZCellDive; ACC-880
Encyclopedic resources Wikidata; Q107116848
Entry history
Entry creation20-May-2021
Last entry update14-Aug-2025
Version number8