Cellosaurus cell line HEK293 APPswe (CVCL

Cellosaurus HEK293 APPswe (CVCL_A5CZ)

Cross-references
Cell line name	HEK293 APPswe
Synonyms	HEK293-APPswe; HEK293/APPswe; 20E2
Accession	CVCL_A5CZ
Resource Identification Initiative	To cite this cell line use: HEK293 APPswe (RRID:CVCL_A5CZ)
Comments	Genetic integration: Method=Transfection; Gene=HGNC; HGNC:620; APP (Note=With p.Lys670_Met671delinsAsnLeu (c.2010_2011inv)). Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo. Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5. Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0045 (HEK293)
Sex of cell	Female
Age at sampling	Fetus
Category	Transformed cell line
Publications	PubMed=22842730; DOI=10.1038/aps.2012.74; PMCID=PMC4001842 Qin Lu, Wu-Yan Chen, Zhi-Yuan Zhu, Jing Chen, Ye-Chun Xu, Morakot Kaewpet, Vatcharin Rukachaisirikul, Li-Li Chen, Xu Shen; L655,240, acting as a competitive BACE1 inhibitor, efficiently decreases beta-amyloid peptide production in HEK293-APPswe cells. Acta Pharmacol. Sin. 33:1459-1468(2012) PubMed=29175631; DOI=10.1016/j.neulet.2017.11.052 Xue-Ling Dai, Ping Chang, Xiao-Xiao Li, Zhao-Lan Gao, Ya-Xuan Sun; The inhibitory effect of chitosan oligosaccharides on beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) in HEK293 APPswe cells. Neurosci. Lett. 665:80-85(2018)
Anatomy/cell type resources	BTO; BTO_0006422
Encyclopedic resources	Wikidata; Q107115302
Entry history
Entry creation	20-May-2021
Last entry update	14-Aug-2025
Version number	8