ID   HEK293 APPswe
AC   CVCL_A5CZ
SY   HEK293-APPswe; HEK293/APPswe; 20E2
DR   BTO; BTO_0006422
DR   Wikidata; Q107115302
RX   PubMed=22842730;
RX   PubMed=29175631;
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:620; APP (Note=With p.Lys670_Met671delinsAsnLeu (c.2010_2011inv)).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 28285; Adenovirus 5.
CC   Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0045 ! HEK293
SX   Female
AG   Fetus
CA   Transformed cell line
DT   Created: 20-05-21; Last updated: 10-04-25; Version: 7
//
RX   PubMed=22842730; DOI=10.1038/aps.2012.74; PMCID=PMC4001842;
RA   Lu Q., Chen W.-Y., Zhu Z.-Y., Chen J., Xu Y.-C., Kaewpet M.,
RA   Rukachaisirikul V., Chen L.-L., Shen X.;
RT   "L655,240, acting as a competitive BACE1 inhibitor, efficiently
RT   decreases beta-amyloid peptide production in HEK293-APPswe cells.";
RL   Acta Pharmacol. Sin. 33:1459-1468(2012).
//
RX   PubMed=29175631; DOI=10.1016/j.neulet.2017.11.052;
RA   Dai X.-L., Chang P., Li X.-X., Gao Z.-L., Sun Y.-X.;
RT   "The inhibitory effect of chitosan oligosaccharides on beta-site
RT   amyloid precursor protein cleaving enzyme 1 (BACE1) in HEK293 APPswe
RT   cells.";
RL   Neurosci. Lett. 665:80-85(2018).
//