Cellosaurus cell line AF22 (CVCL

Cellosaurus AF22 (CVCL_A5CW)

Cross-references
Cell line name	AF22
Accession	CVCL_A5CW
Resource Identification Initiative	To cite this cell line use: AF22 (RRID:CVCL_A5CW)
Comments	Part of: Human Protein Atlas, Cell Atlas panel. Characteristics: Long term self-renewing neuroepithelial-like stem cells with stable neurogenic properties (PubMed=22272239). Omics: Proteomics; Expression; Large antibody panel staining analysis. Omics: Transcriptomics; RNAseq. Miscellaneous: Sex of donor from personal communication of BioKryo (ISENET Biobanking). Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067. Cell type: Fibroblast of skin; CL=CL_0002620.
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Female
Age at sampling	36Y
Category	Somatic stem cell
Web pages	Info; HPA; -; https://www.proteinatlas.org/learn/cellines Provider; BioKryo; -; https://biokryo.airliquide.com/sites/biokryo/files/2022-07/human-stem-cells-catalogue-isenet.pdf
Publications	PubMed=22272239; DOI=10.1371/journal.pone.0029597; PMCID=PMC3260177 Anna Falk, Philipp Koch, Jaideep Kesavan, Yasuhiro Takashima, Julia Ladewig, Michael Alexander, Ole Wiskow, Jignesh K. Tailor, Matthew Trotter, Steven M. Pollard, Austin Gerard Smith, Oliver Brustle; Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons. PLoS ONE 7:e29597.1-e29597.13(2012) PubMed=23884946; DOI=10.1523/JNEUROSCI.0130-13.2013; PMCID=PMC3721847 Jignesh K. Tailor, Raja Kittappa, Ketty Leto, Monte Gates, Melodie Borel, Ole Paulsen, Sonia Spitzer, Ragnhildur Thora Karadottir, Ferdinando Rossi, Anna Falk, Austin Gerard Smith; Stem cells expanded from the human embryonic hindbrain stably retain regional specification and high neurogenic potency. J. Neurosci. 33:12407-12422(2013) PubMed=28041877; DOI=10.1016/j.stemcr.2016.11.014; PMCID=PMC5233436 Joana V. Flores, Lucia Cordero-Espinoza, Feride Oeztuerk-Winder, Amanda Andersson-Rolf, Tommaso Selmi, Sandra Blanco, Jignesh K. Tailor, Sabine Dietmann, Michaela Frye; Cytosine-5 RNA methylation regulates neural stem cell differentiation and motility. Stem Cell Reports 8:112-124(2017)
Anatomy/cell type resources	BTO; BTO_0006445
Encyclopedic resources	Wikidata; Q107113349
Gene expression databases	GEO; GSM7701478 GEO; GSM7701479
Entry history
Entry creation	20-May-2021
Last entry update	10-Apr-2025
Version number	8