Cellosaurus TEX (CVCL_A5CF)
| Cell line name | TEX |
|---|---|
| Accession | CVCL_A5CF |
| Resource Identification Initiative | To cite this cell line use: TEX (RRID:CVCL_A5CF) |
| Comments | Characteristics: Expresses a transfected FUS-ERG (TLS-ERG) fusion protein. Mimics the features of primary human acute myeloid leukemia and of leukemia-initiating cells (LIC) and are more than 90% CD34+. Underwent step-wise transformation and immortalization through acquisition of additional genetic changes, such as expression of TERT, expression of LIC markers CD34, CD44 and CD123 and the stem cell gene BMI1 (PubMed=16094415; PubMed=22160482). Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:3446; ERG (Note=FUS-ERG fusion). Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:4010; FUS (Note=FUS-ERG fusion). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Omics: Transcriptomics; Microarray. Derived from site: In situ; Umbilical cord blood; UBERON=UBERON_0012168. |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Sex of cell | Sex unspecified |
| Age at sampling | <1D |
| Category | Transformed cell line |
| Publications | PubMed=16094415; DOI=10.1038/sj.leu.2403917 PubMed=22160482; DOI=10.1182/blood-2011-01-330019 |
| Cross-references | |
| Anatomy/cell type resources | BTO; BTO_0006359 |
| Encyclopedic resources | Wikidata; Q107117030 |
| Gene expression databases | GEO; GSM838425
GEO; GSM838426 GEO; GSM838427 |
| Entry history | |
| Entry creation | 20-May-2021 |
| Last entry update | 10-Apr-2025 |
| Version number | 8 |