Cellosaurus cell line MiPSC5-T1 (CVCL

Cross-references
Cell line name	MiPSC5-T1
Accession	CVCL_A4RF
Resource Identification Initiative	To cite this cell line use: MiPSC5-T1 (RRID:CVCL_A4RF)
Comments	Derived from site: In situ; Skin; UBERON=UBERON_0002097. Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations	Mutation; HGNC; HGNC:7490; MT-TL1; Simple_edited; m.3243A>G; ClinVar=VCV000009589; Zygosity=Heteroplasmic; Note=By TALEN. The percentage of heteroplasmy was reduced from >80% to 27% (PubMed=29318513).
Disease	MELAS syndrome (NCIt: C84885) MELAS (ORDO: Orphanet_550)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_A4RE (MiPSC5)
Sex of cell	Male
Age at sampling	Age unspecified
Category	Induced pluripotent stem cell
Publications	PubMed=29318513; DOI=10.1007/s13238-017-0499-y; PMCID=PMC5829275 Yi Yang, Han Wu, Xiang-Jin Kang, Yan-Hui Liang, Ting Lan, Tian-Jie Li, Tao Tan, Jiang-Yun Peng, Quan-Jun Zhang, Geng An, Ya-Li Liu ...Show all 25 authors... , Qian Yu, Zheng-Lai Ma, Ying Lian, Boon Seng Soh, Qing-Feng Chen, Ping Liu, Yao-Yong Chen, Xiao-Fang Sun, Rong Li, Xiu-Mei Zhen, Ping Liu, Yang Yu, Xiao-Ping Li, Yong Fan; Show fewer authors Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs. Protein Cell 9:283-297(2018)
Cell line databases/resources	SKIP; SKIP002969
Encyclopedic resources	Wikidata; Q105510147
Entry history
Entry creation	12-Jan-2021
Last entry update	19-Dec-2024
Version number	6