Cellosaurus cell line CAL-12T KRAS (G12C/+) (CVCL

Cross-references
Cell line name	CAL-12T KRAS (G12C/+)
Synonyms	KRAS (G12C/+) Cal12T
Accession	CVCL_A4II
Resource Identification Initiative	To cite this cell line use: CAL-12T KRAS (G12C/+) (RRID:CVCL_A4II)
Comments	Population: Caucasian. Characteristics: Heterozygous knockin of a KRAS activating mutation. Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations	Mutation; HGNC; HGNC:18037; ARID2; Simple; p.Gly1291Glufs*4 (c.3872del) (p.Val1290fs, c.3870delG); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly466Val (c.1397G>T); ClinVar=VCV000013967; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:6407; KRAS; Simple_edited; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Heterozygous; Note=By method not specified (Horizon_Discovery=HD+113-001). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys135Phe (c.404G>T); ClinVar=VCV000376559; Zygosity=Homozygous (from parent cell line).
Disease	Lung non-small cell carcinoma (NCIt: C2926)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_1105 (CAL-12T)
Sex of cell	Male
Age at sampling	Age unspecified
Category	Cancer cell line
Cell line collections (Providers)	Horizon_Discovery; HD+113-001
Cell line databases/resources	cancercelllines; CVCL_A4II
Encyclopedic resources	Wikidata; Q105506577
Entry history
Entry creation	12-Jan-2021
Last entry update	19-Dec-2024
Version number	7