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Cellosaurus CAL-12T KRAS (G12C/+) (CVCL_A4II)

[Text version]
Cell line name CAL-12T KRAS (G12C/+)
Synonyms KRAS (G12C/+) Cal12T
Accession CVCL_A4II
Resource Identification Initiative To cite this cell line use: CAL-12T KRAS (G12C/+) (RRID:CVCL_A4II)
Comments Population: Caucasian.
Characteristics: Heterozygous knockin of a KRAS activating mutation.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 18037; ARID2; Simple; p.Gly1291Glufs*4 (c.3872del) (p.Val1290fs, c.3870delG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Gly466Val (c.1397G>T); ClinVar=VCV000013967; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple_edited; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Heterozygous; Note=By method not specified (Horizon_Discovery=HD+113-001).
  • Mutation; HGNC; 11998; TP53; Simple; p.Cys135Phe (c.404G>T); ClinVar=VCV000376559; Zygosity=Homozygous (from parent cell line).
Disease Lung non-small cell carcinoma (NCIt: C2926)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1105 (CAL-12T)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Cross-references
Cell line collections (Providers) Horizon_Discovery; HD+113-001
Cell line databases/resources cancercelllines; CVCL_A4II
Encyclopedic resources Wikidata; Q105506577
Entry history
Entry creation12-Jan-2021
Last entry update30-Jan-2024
Version number6