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Cellosaurus Hep G2-C34 (CVCL_A2HD)

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Cell line name Hep G2-C34
Synonyms C34; HepG2 C34
Accession CVCL_A2HD
Resource Identification Initiative To cite this cell line use: Hep G2-C34 (RRID:CVCL_A2HD)
Comments Population: Caucasian.
Characteristics: Control cell line for Hep G2-E43 (Cellosaurus=CVCL_A2HF) and Hep G2-E47 (Cellosaurus=CVCL_A2HG) (PubMed=9547353).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=9547353; DOI=10.1124/mol.53.4.638
Qi Chen, Arthur I. Cederbaum;
Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells.
Mol. Pharmacol. 53:638-648(1998)

PubMed=18369917; DOI=10.1007/978-1-59745-242-7_11
De-Feng Wu, Arthur I. Cederbaum;
Development and properties of HepG2 cells that constitutively express CYP2E1.
Methods Mol. Biol. 447:137-150(2008)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A2HD
Encyclopedic resources Wikidata; Q105507615
Entry history
Entry creation12-Jan-2021
Last entry update14-Aug-2025
Version number8