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Cellosaurus Hep G2-MV-5 (CVCL_A2HC)

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Cell line name Hep G2-MV-5
Synonyms MV-5
Accession CVCL_A2HC
Resource Identification Initiative To cite this cell line use: Hep G2-MV-5 (RRID:CVCL_A2HC)
Comments Population: Caucasian.
Characteristics: Control cell line for Hep G2-MV2E1-9 (Cellosaurus=CVCL_A2HB) (PubMed=7687464).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=7687464; DOI=10.1021/bi00078a017
Yan Dai, Julia Rashba-Step, Arthur I. Cederbaum;
Stable expression of human cytochrome P4502E1 in HepG2 cells: characterization of catalytic activities and production of reactive oxygen intermediates.
Biochemistry 32:6928-6937(1993)

PubMed=9169410; DOI=10.1074/jbc.272.23.14532
Qi Chen, Monica Galleano, Arthur I. Cederbaum;
Cytotoxicity and apoptosis produced by arachidonic acid in Hep G2 cells overexpressing human cytochrome P4502E1.
J. Biol. Chem. 272:14532-14541(1997)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A2HC
Encyclopedic resources Wikidata; Q105507634
Entry history
Entry creation12-Jan-2021
Last entry update14-Aug-2025
Version number8