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Cellosaurus hmel1R (CVCL_A2GA)

[Text version]
Cell line name hmel1R
Synonyms Hmel1R; Hmel-1R
Accession CVCL_A2GA
Resource Identification Initiative To cite this cell line use: hmel1R (RRID:CVCL_A2GA)
Comments Population: Caucasian; Italian.
Selected for resistance to: ChEBI; CHEBI_91367; Barasertib-HQPA (AZD1152-HQPA).
Derived from site: Metastatic; Skin; UBERON=UBERON_0002097.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Lys (c.1798_1799delGTinsAA); ClinVar=VCV000375941; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Trp383Cys (c.1149G>T); Zygosity=Unspecified (from parent cell line).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_D722 (hmel1)
Sex of cell Male
Age at sampling 70Y
Category Cancer cell line
Publications

DOI=10.1186/1479-5876-12-S1-P7
Azzariti A., Porcelli L., Quatrale A.E., Sidella L., Iacobazzi R.M., Guida G., Maida I., Cocco T., Ferretta A., Strippoli S., Guida S., Tommasi S., Paradiso A., Guida M.
Barasertib: a novel approach for the treatment of metastatic melanoma.
J. Transl. Med. 12 Suppl. 1:P7-P7(2014)

PubMed=25623468; DOI=10.1186/s12967-015-0385-4; PMCID=PMC4314759
Porcelli L., Guida G., Quatrale A.E., Cocco T., Sidella L., Maida I., Iacobazzi R.M., Ferretta A., Stolfa D.A., Strippoli S., Guida S., Tommasi S., Guida M., Azzariti A.
Aurora kinase B inhibition reduces the proliferation of metastatic melanoma cells and enhances the response to chemotherapy.
J. Transl. Med. 13:26.1-26.13(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A2GA
Encyclopedic resources Wikidata; Q105507686
Entry history
Entry creation12-Jan-2021
Last entry update19-Dec-2024
Version number6