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Cellosaurus RSO4 (CVCL_A2CL)

[Text version]
Cell line name RSO4
Accession CVCL_A2CL
Resource Identification Initiative To cite this cell line use: RSO4 (RRID:CVCL_A2CL)
Comments Population: Japanese.
Characteristics: IL2 dependent.
Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:11920; FAS; Simple; p.His60Arg (c.179A>G); ClinVar=VCV001439236; Zygosity=Heterozygous (PubMed=12207908).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro223His (c.668C>A); Zygosity=Unspecified (from parent cell line).
Disease Adult T-cell leukemia/lymphoma (NCIt: C3184)
Adult T-cell leukemia/lymphoma (ORDO: Orphanet_86875)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_VN48 (SO-4)
Sex of cell Female
Age at sampling 59Y
Category Cancer cell line
Publications

PubMed=10863977; DOI=10.1034/j.1600-0609.2000.90110.x
Yasuaki Yamada, Kazuyuki Sugahara, Kazuto Tsuruda, Kazuo Nohda, Naoki Mori, Tomoko Hata, Takahiro Maeda, Toshihisa Hayashibara, Tatsuroh Joh, Miyuki Honda, Masayuki Tawara ...Show all 14 authors... , Masao Tomonaga, Yoshitsugu Miyazaki, Shimeru Kamihira; Show fewer authors
Lactacystin activates FLICE (caspase 8) protease and induces apoptosis in Fas-resistant adult T-cell leukemia cell lines.
Eur. J. Haematol. 64:315-322(2000)

PubMed=12207908; DOI=10.1016/S0006-291X(02)02039-9
Takahiro Maeda, Susumu Nakayama, Yasuaki Yamada, Kazuyuki Sugahara, Hajime Isomoto, Masayuki Tawara, Reishi Yamasaki, Yasuyuki Onimaru, Tetsuro Matsushita, Yoshiyuki Ohzono, Shimeru Kamihira;
The conformational alteration of the mutated extracellular domain of Fas in an adult T cell leukemia cell line.
Biochem. Biophys. Res. Commun. 296:1251-1256(2002)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A2CL
Encyclopedic resources Wikidata; Q105510805
Polymorphism and mutation databases Cosmic; 2765438
Entry history
Entry creation12-Jan-2021
Last entry update19-Dec-2024
Version number8