ID   RSO4
AC   CVCL_A2CL
DR   cancercelllines; CVCL_A2CL
DR   Cosmic; 2765438
DR   Wikidata; Q105510805
RX   PubMed=10863977;
RX   PubMed=12207908;
CC   Population: Japanese.
CC   Characteristics: IL2 dependent.
CC   Sequence variation: Mutation; HGNC; HGNC:11920; FAS; Simple; p.His60Arg (c.179A>G); ClinVar=VCV001439236; Zygosity=Heterozygous (PubMed=12207908).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro223His (c.668C>A); Zygosity=Unspecified (from parent cell line).
CC   Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C3184; Adult T-cell leukemia/lymphoma
DI   ORDO; Orphanet_86875; Adult T-cell leukemia/lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_VN48 ! SO-4
SX   Female
AG   59Y
CA   Cancer cell line
DT   Created: 12-01-21; Last updated: 19-12-24; Version: 8
//
RX   PubMed=10863977; DOI=10.1034/j.1600-0609.2000.90110.x;
RA   Yamada Y., Sugahara K., Tsuruda K., Nohda K., Mori N., Hata T.,
RA   Maeda T., Hayashibara T., Joh T., Honda M., Tawara M., Tomonaga M.,
RA   Miyazaki Y., Kamihira S.;
RT   "Lactacystin activates FLICE (caspase 8) protease and induces
RT   apoptosis in Fas-resistant adult T-cell leukemia cell lines.";
RL   Eur. J. Haematol. 64:315-322(2000).
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RX   PubMed=12207908; DOI=10.1016/S0006-291X(02)02039-9;
RA   Maeda T., Nakayama S., Yamada Y., Sugahara K., Isomoto H., Tawara M.,
RA   Yamasaki R., Onimaru Y., Matsushita T., Ohzono Y., Kamihira S.;
RT   "The conformational alteration of the mutated extracellular domain of
RT   Fas in an adult T cell leukemia cell line.";
RL   Biochem. Biophys. Res. Commun. 296:1251-1256(2002).
//