ID   RSO4
AC   CVCL_A2CL
DR   cancercelllines; CVCL_A2CL
DR   Cosmic; 2765438
DR   Wikidata; Q105510805
RX   PubMed=10863977;
RX   PubMed=12207908;
CC   Population: Japanese.
CC   Characteristics: IL2 dependent.
CC   Sequence variation: Mutation; HGNC; HGNC:11920; FAS; Simple; p.His60Arg (c.179A>G); ClinVar=VCV001439236; Zygosity=Heterozygous (PubMed=12207908).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro223His (c.668C>A); Zygosity=Unspecified (from parent cell line).
CC   Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C3184; Adult T-cell leukemia/lymphoma
DI   ORDO; Orphanet_86875; Adult T-cell leukemia/lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_VN48 ! SO-4
SX   Female
AG   59Y
CA   Cancer cell line
DT   Created: 12-01-21; Last updated: 19-12-24; Version: 8
//
RX   PubMed=10863977; DOI=10.1034/j.1600-0609.2000.90110.x;
RA   Yamada, Yasuaki
RA   Sugahara, Kazuyuki
RA   Tsuruda, Kazuto
RA   Nohda, Kazuo
RA   Mori, Naoki
RA   Hata, Tomoko
RA   Maeda, Takahiro
RA   Hayashibara, Toshihisa
RA   Joh, Tatsuroh
RA   Honda, Miyuki
RA   Tawara, Masayuki
RA   Tomonaga, Masao
RA   Miyazaki, Yoshitsugu
RA   Kamihira, Shimeru
RT   "Lactacystin activates FLICE (caspase 8) protease and induces
RT   apoptosis in Fas-resistant adult T-cell leukemia cell lines.";
RL   Eur. J. Haematol. 64:315-322(2000).
//
RX   PubMed=12207908; DOI=10.1016/S0006-291X(02)02039-9;
RA   Maeda, Takahiro
RA   Nakayama, Susumu
RA   Yamada, Yasuaki
RA   Sugahara, Kazuyuki
RA   Isomoto, Hajime
RA   Tawara, Masayuki
RA   Yamasaki, Reishi
RA   Onimaru, Yasuyuki
RA   Matsushita, Tetsuro
RA   Ohzono, Yoshiyuki
RA   Kamihira, Shimeru
RT   "The conformational alteration of the mutated extracellular domain of
RT   Fas in an adult T cell leukemia cell line.";
RL   Biochem. Biophys. Res. Commun. 296:1251-1256(2002).
//