| Cell line name |
LIM1215 R5 Cetux |
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| Accession |
CVCL_A2CE |
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| Resource Identification Initiative |
To cite this cell line use: LIM1215 R5 Cetux (RRID:CVCL_A2CE) |
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| Comments |
Population: Caucasian.
Selected for resistance to: DrugBank; DB00002; Cetuximab (Erbitux).
Derived from site: Metastatic; Omentum; UBERON=UBERON_0003688. |
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| Sequence variations |
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Pro423Gln (c.1268C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Thr41Ala (c.121A>G); ClinVar=VCV000017580; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Gly465Arg (c.1393G>A); ClinVar=VCV002011745; Zygosity=Heterozygous; Note=Acquired during resistance selection process (PubMed=25623215).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
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| Disease |
Colon adenocarcinoma (NCIt: C4349)
Lynch syndrome (NCIt: C8494)
Lynch syndrome (ORDO: Orphanet_144) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_2574 (LIM1215) |
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| Sex of cell |
Male |
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| Age at sampling |
34Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=25623215; DOI=10.1158/1078-0432.CCR-14-2821
Sabrina Arena, Beatriz Bellosillo, Giulia Siravegna, Alejandro Martinez, Israel Canadas, Luca Lazzari, Noelia Ferruz, Mariangela Russo, Sandra Misale, Iria Gonzalez, Mar Iglesias ...Show all 25 authors... , Elena Gavilan, Giorgio Corti, Sebastijan Hobor, Giovanni Crisafulli, Marta Salido, Juan Sanchez, Alba Dalmases, Joaquim Bellmunt, Gianni De Fabritiis, Ana Rovira, Federica Di Nicolantonio, Joan Albanell, Alberto Bardelli, Clara Montagut; Show fewer authors
Emergence of multiple EGFR extracellular mutations during cetuximab treatment in colorectal cancer.
Clin. Cancer Res. 21:2157-2166(2015) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_A2CE
|
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| Encyclopedic resources |
Wikidata; Q105509910
|
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| Polymorphism and mutation databases |
Cosmic; 2841371
|
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| Entry history |
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| Entry creation | 12-Jan-2021 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 7 |
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