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Cellosaurus HCA46 R1 Cetux (CVCL_A2BY)

[Text version]
Cell line name HCA46 R1 Cetux
Synonyms HCA-46 R1 Cetux
Accession CVCL_A2BY
Resource Identification Initiative To cite this cell line use: HCA46 R1 Cetux (RRID:CVCL_A2BY)
Comments Selected for resistance to: DrugBank; DB00002; Cetuximab (Erbitux).
Derived from site: In situ; Colon, sigmoid; UBERON=UBERON_0001159.
Sequence variations
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ala183Ser (c.547G>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val272Alafs*33 (c.815_816delTG); Zygosity=Unspecified (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2468 (HCA46)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=25623215; DOI=10.1158/1078-0432.CCR-14-2821
Sabrina Arena, Beatriz Bellosillo, Giulia Siravegna, Alejandro Martinez, Israel Canadas, Luca Lazzari, Noelia Ferruz, Mariangela Russo, Sandra Misale, Iria Gonzalez, Mar Iglesias ...Show all 25 authors... , Elena Gavilan, Giorgio Corti, Sebastijan Hobor, Giovanni Crisafulli, Marta Salido, Juan Sanchez, Alba Dalmases, Joaquim Bellmunt, Gianni De Fabritiis, Ana Rovira, Federica Di Nicolantonio, Joan Albanell, Alberto Bardelli, Clara Montagut; Show fewer authors
Emergence of multiple EGFR extracellular mutations during cetuximab treatment in colorectal cancer.
Clin. Cancer Res. 21:2157-2166(2015)

Cross-references
Encyclopedic resources Wikidata; Q105507568
Polymorphism and mutation databases Cosmic; 2841364
Entry history
Entry creation12-Jan-2021
Last entry update19-Dec-2024
Version number6