Cellosaurus logo
expasy logo

Cellosaurus HCA46 (CVCL_2468)

[Text version]
Cell line name HCA46
Synonyms HCA-46; HCA 46
Accession CVCL_2468
Resource Identification Initiative To cite this cell line use: HCA46 (RRID:CVCL_2468)
Comments Part of: AstraZeneca Colorectal cell line (AZCL) panel.
Microsatellite instability: Stable (MSS) (PubMed=24755471; PubMed=25926053).
Omics: Proteomics.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Colon, sigmoid; UBERON=UBERON_0001159.
Sequence variations
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ala183Ser (c.547G>T); Zygosity=Heterozygous (PubMed=9294210).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val272Alafs*33 (c.815_816delTG); Zygosity=Unspecified (PubMed=16418264).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_A2BY (HCA46 R1 Cetux)CVCL_A2BZ (HCA46 R2 Cetux)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): ECACC=07031601; PubMed=25926053

Markers:
AmelogeninX
CSF1PO11,12
D5S81811,12
D7S82010,14
D13S31710,11
D16S53911,13
D21S1130
TH016,9.3
TPOX8,9
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=3718830; DOI=10.1038/bjc.1986.132; PMCID=PMC2001395
Susan C. Kirkland, I.G. Bailey;
Establishment and characterisation of six human colorectal adenocarcinoma cell lines.
Br. J. Cancer 53:779-785(1986)

PubMed=8464898; DOI=10.1073/pnas.90.7.2842; PMCID=PMC46192
Michael J. Browning, Peter Krausa, Andrew J. Rowan, David C. Bicknell, Julia Gwynaeth Bodmer, Walter Fred Bodmer;
Tissue typing the HLA-A locus from genomic DNA by sequence-specific PCR: comparison of HLA genotype and surface expression on colorectal tumor cell lines.
Proc. Natl. Acad. Sci. U.S.A. 90:2842-2845(1993)

PubMed=9294210; DOI=10.1073/pnas.94.19.10330; PMCID=PMC23362
Mohammad Ilyas, Ian Philip Mark Tomlinson, Andrew J. Rowan, Massimo Pignatelli, Walter Fred Bodmer;
Beta-catenin mutations in cell lines established from human colorectal cancers.
Proc. Natl. Acad. Sci. U.S.A. 94:10330-10334(1997)

PubMed=10737795; DOI=10.1073/pnas.97.7.3352; PMCID=PMC16243
Andrew J. Rowan, Hanan Lamlum, Mohammad Ilyas, James M.D. Wheeler, Jannes Straub, Angeliki Papadopoulou, David C. Bicknell, Walter Fred Bodmer, Ian Philip Mark Tomlinson;
APC mutations in sporadic colorectal tumors: a mutational 'hotspot' and interdependence of the 'two hits'.
Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000)

PubMed=16418264; DOI=10.1073/pnas.0510146103; PMCID=PMC1327731
Ying Liu, Walter Fred Bodmer;
Analysis of p53 mutations and their expression in 56 colorectal cancer cell lines.
Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006)

PubMed=18258742; DOI=10.1073/pnas.0712176105; PMCID=PMC2268141
Muhammad Emaduddin, David C. Bicknell, Walter Fred Bodmer, Stephan M. Feller;
Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008)

PubMed=20606684; DOI=10.1038/sj.bjc.6605780; PMCID=PMC2920028
Karin Bracht, Angela M. Nicholls, Ying Liu, Walter Fred Bodmer;
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Br. J. Cancer 103:340-346(2010)

PubMed=23272949; DOI=10.1186/1755-8794-5-66; PMCID=PMC3543849
Andreas Schlicker, Garry Beran, Christine M. Chresta, Gael McWalter, Alison Pritchard, Susie Weston, Sarah Runswick, Sara Davenport, Kerry Heathcote, Denis Alferez Castro, George Orphanides ...Show all 13 authors... , Tim French, Lodewyk F.A. Wessels; Show fewer authors
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.
BMC Med. Genomics 5:66.1-66.15(2012)

PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013
Dmitri Mouradov, Clare Sloggett, Robert N. Jorissen, Christopher G. Love, Shan Li, Antony Wilks Burgess, Diego Arango, Robert L. Strausberg, Daniel Buchanan, Samuel Wormald, Liam O'Connor ...Show all 17 authors... , Jennifer L. Wilding, David C. Bicknell, Ian Philip Mark Tomlinson, Walter Fred Bodmer, John M. Mariadason, Oliver M. Sieber; Show fewer authors
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.
Cancer Res. 74:3238-3247(2014)

PubMed=25623215; DOI=10.1158/1078-0432.CCR-14-2821
Sabrina Arena, Beatriz Bellosillo, Giulia Siravegna, Alejandro Martinez, Israel Canadas, Luca Lazzari, Noelia Ferruz, Mariangela Russo, Sandra Misale, Iria Gonzalez, Mar Iglesias ...Show all 25 authors... , Elena Gavilan, Giorgio Corti, Sebastijan Hobor, Giovanni Crisafulli, Marta Salido, Juan Sanchez, Alba Dalmases, Joaquim Bellmunt, Gianni De Fabritiis, Ana Rovira, Federica Di Nicolantonio, Joan Albanell, Alberto Bardelli, Clara Montagut; Show fewer authors
Emergence of multiple EGFR extracellular mutations during cetuximab treatment in colorectal cancer.
Clin. Cancer Res. 21:2157-2166(2015)

PubMed=25926053; DOI=10.1038/ncomms8002
Enzo Medico, Mariangela Russo, Gabriele Picco, Carlotta Cancelliere, Emanuele Valtorta, Giorgio Corti, Michela Buscarino, Claudio Isella, Simona Lamba, Barbara Martinoglio, Silvio Veronese ...Show all 19 authors... , Salvatore Siena, Andrea Sartore-Bianchi, Marco Beccuti, Marcella Mottolese, Michael Linnebacher, Francesca Cordero, Federica Di Nicolantonio, Alberto Bardelli; Show fewer authors
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=29101300; DOI=10.15252/msb.20177701; PMCID=PMC5731344
Martin Frejno, Riccardo Zenezini Chiozzi, Mathias Wilhelm, Heiner Koch, Run-Sheng Zheng, Susan Klaeger, Benjamin Ruprecht, Chen Meng, Karl Kramer, Anna Jarzab, Stephanie Heinzlmeir ...Show all 20 authors... , Elaine Johnstone, Enric Domingo, David James Kerr, Moritz Jesinghaus, Julia Slotta-Huspenina, Wilko Weichert, Stefan Knapp, Stephan M. Feller, Bernhard Kuster; Show fewer authors
Pharmacoproteomic characterisation of human colon and rectal cancer.
Mol. Syst. Biol. 13:951-951(2017)

Cross-references
Cell line collections (Providers) ECACC; 07031601
Ximbio; 152463 - Discontinued
Cell line databases/resources ColonAtlas; HCA46
Encyclopedic resources Wikidata; Q54881490
Gene expression databases GEO; GSM1346836
GEO; GSM1374490
GEO; GSM1448177
Polymorphism and mutation databases Cosmic; 876708
Cosmic; 948844
Cosmic; 986013
Cosmic; 995411
Cosmic; 1043812
Cosmic; 1223139
Cosmic; 1312300
Cosmic; 2301975
Cosmic; 2760083
Cosmic; 2800581
Cosmic; 2841363
IARC_TP53; 21759
Proteomic databases PRIDE; PXD005354
PRIDE; PXD005355
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number27