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Cellosaurus YUMMER1.7 (CVCL_A2AX)

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Cell line name YUMMER1.7
Synonyms Yale University Mouse Melanoma Exposed to Radiation 1.7
Accession CVCL_A2AX
Resource Identification Initiative To cite this cell line use: YUMMER1.7 (RRID:CVCL_A2AX)
Comments Characteristics: The parent cell line was exposed to three rounds of UVB radiation at 1,500 J/m2 to generate a cell line with an increased number of somatic mutations (PubMed=28379630).
Knockout cell: Method=KO mouse; MGI; MGI:104738; Cdkn2a.
Knockout cell: Method=KO mouse; MGI; MGI:109583; Pten.
Transformant: NCIt; C17231; Ultraviolet radiation.
Sequence variations
  • Mutation; MGI; MGI:88190; Braf; Simple; p.Val637Glu (c.1910T>A); Zygosity=Heterozygous (from parent cell line).
Disease Mouse melanoma (NCIt: C21790)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Hierarchy Parent: CVCL_JK16 (YUMM1.7)
Children:
CVCL_A2BD (YUMMER1.7D4)CVCL_A2BC (YUMMER1.7D5)CVCL_A2AY (YUMMER1.7 H2B-GFP5)
Sex of cell Male
Age at sampling Adult
Category Cancer cell line
Publications

PubMed=28379630; DOI=10.1111/pcmr.12591; PMCID=PMC5820096
Jake Wang, Curtis Jamison Perry, Katrina Meeth, Durga Thakral, William Damsky, Goran Micevic, Susan M. Kaech, Kim Blenman, Marcus W. Bosenberg;
UV-induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model.
Pigment Cell Melanoma Res. 30:428-435(2017)

Cross-references
Encyclopedic resources Wikidata; Q105511840
Entry history
Entry creation12-Jan-2021
Last entry update21-Mar-2023
Version number3