Cellosaurus cell line KCL003 (CVCL

Cellosaurus KCL003 (CVCL_A239)

Cross-references
Cell line name	KCL003
Synonyms	KCL003(CF1); KCL-003; CF-1; CF1; KCL003/CF-1; KCL-003-CF-1; KCL003_CF1; KCLe003-A
Accession	CVCL_A239
Resource Identification Initiative	To cite this cell line use: KCL003 (RRID:CVCL_A239)
Comments	From: King's College London; London; United Kingdom. Registration: Swiss research registry; BAG-hES-IMP-0017. Registration: UK Stem Cell Bank (UKSCB); R-06-027, Steering comm. appl. SCSC-06-28(2). Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358. Cell type: Embryonic stem cell; CL=CL_0002322.
Sequence variations	Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Homozygous (PubMed=15820050).
Disease	Cystic fibrosis (NCIt: C2975) Cystic fibrosis (ORDO: Orphanet_586)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	Blastocyst stage
Category	Embryonic stem cell
Web pages	Provider; KCL; -; https://www.kcl.ac.uk/research/stem-cell-research Provider; NIBSC; -; https://nibsc.org/science_and_research/advanced_therapies/uk_stem_cell_bank/cell_line_catalogue/research_grade_stem_cell_lines/laboratory_grade/kcl003-cf-1.aspx
Publications	PubMed=15820050; DOI=10.1016/S1472-6483(10)61801-9 Susan J. Pickering, Stephen Lewis Minger, Minal J. Patel, Hannah Taylor, Cheryl Black, Chris J. Burns, Antigoni Ekonomou, Peter R. Braude; Generation of a human embryonic stem cell line encoding the cystic fibrosis mutation deltaF508, using preimplantation genetic diagnosis. Reprod. BioMed. Online 10:390-397(2005) PubMed=17572666; DOI=10.1038/nbt1318 Oluseun Adewumi, Behrouz Aflatoonian, Lars Ahrlund-Richter, Michal Amit, Peter W. Andrews, Gemma Beighton, Paul A. Bello, Nissim Benvenisty, Lorraine S. Berry, Simon Bevan, Barak Blum ...Show all 85 authors... , Justin Brooking, Kevin G. Chen, Andre B.-H. Choo, Gary A. Churchill, Marie Corbel, Ivan Damjanov, Jonathan S. Draper, Petr Dvorak, Katarina Emanuelsson, Roland A. Fleck, Angela Ford, Karin Gertow, Marina Gertsenstein, Paul J. Gokhale, Rebecca S. Hamilton, Ales Hampl, Lyn E. Healy, Outi Hovatta, Johan Hyllner, Marta P. Imreh, Joseph Itskovitz-Eldor, Jamie Jackson, Jacqueline L. Johnson, Mark Jones, Kehkooi Kee, Benjamin L. King, Barbara B. Knowles, Majlinda Lako, Franck Lebrin, Barbara S. Mallon, Daisy Manning, Yoav Mayshar, Ronald Davies Graham McKay, Anna E. Michalska, Milla Mikkola, Maria Mileikovsky, Stephen Lewis Minger, Harry D. Moore, Christine L. Mummery, Andras Nagy, Norio Nakatsuji, Carmel M. O'Brien, Steve Kah-Weng Oh, Cia Olsson, Timo Otonkoski, Kye-Yoon Park, Robert Passier, Hema Patel, Minal J. Patel, Roger Arnold Pedersen, Martin F. Pera, Marian S. Piekarczyk, Renee A. Reijo Pera, Benjamin E. Reubinoff, Allan J. Robins, Janet Rossant, Peter Rugg-Gunn, Thomas C. Schulz, Henrik Semb, Eric S. Sherrer, Henrike Siemen, Glyn N. Stacey, Miodrag Stojkovic, Hirofumi Suemori, Jin Szatkiewicz, Tikva Tako Turetsky, Timo Tuuri, Stieneke van den Brink, Kristina Vintersten, Sanna Vuoristo, Dorien Ward-van Oostwaard, Thomas A. Weaver, Lesley A. Young, Wei-Dong Zhang; Show fewer authors International Stem Cell Initiative Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat. Biotechnol. 25:803-816(2007)
Cell line databases/resources	hPSCreg; KCLe003-A SKIP; SKIP001882
Encyclopedic resources	Wikidata; Q54899653
Entry history
Entry creation	06-Jun-2012
Last entry update	10-Apr-2025
Version number	24