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Cellosaurus EDi001-B-3 (CVCL_A1XR)

[Text version]
Cell line name EDi001-B-3
Synonyms AST18-5D
Accession CVCL_A1XR
Resource Identification Initiative To cite this cell line use: EDi001-B-3 (RRID:CVCL_A1XR)
Comments From: University of Edinburgh; Edinburgh; United Kingdom.
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; 11138; SNCA.
Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067.
Cell type: Fibroblast of skin; CL=CL_0002620.
Disease Parkinson disease 4, autosomal dominant (NCIt: C198604)
Hereditary late-onset Parkinson disease (ORDO: Orphanet_411602)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_ZA47 (EDi001-B)
Sex of cell Female
Age at sampling 55Y
Category Induced pluripotent stem cell

PubMed=30472757; DOI=10.1111/ejn.14286
Chen Y.-X., Dolt K.S., Kriek M., Baker T., Downey P., Drummond N.J., Canham M.A., Natalwala A., Rosser S., Kunath T.
Engineering synucleinopathy-resistant human dopaminergic neurons by CRISPR-mediated deletion of the SNCA gene.
Eur. J. Neurosci. 49:510-524(2019)

Cell line collections (Providers) EBiSC; EDi001-B-3
ECACC; 66770010 - Discontinued
Cell line databases/resources hPSCreg; EDi001-B-3
Biological sample resources BioSamples; SAMEA7111752
Encyclopedic resources Wikidata; Q105506816
Entry history
Entry creation12-Jan-2021
Last entry update30-Jan-2024
Version number7