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Cellosaurus A375-RMR (CVCL_A1VP)

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Cell line name A375-RMR
Synonyms A375 RMR; A375 SKIN CJ1; A375-CJ1
Accession CVCL_A1VP
Resource Identification Initiative To cite this cell line use: A375-RMR (RRID:CVCL_A1VP)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_75045; Dabrafenib (Tafinlar; GSK2118436).
Selected for resistance to: ChEBI; CHEBI_75998; Trametinib (Mekinist; GSK1120212).
Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (DepMap=ACH-002001).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Children:
CVCL_B3PJ (A375-RMR SCH 0.25)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): DepMap=ACH-002001

Markers:
AmelogeninX
CSF1PO11,12
D3S135815,17
D5S81812
D7S8209
D8S117911,14
D13S31711,14
D16S5399
D18S5112,17
D21S1129,30
FGA22,23
Penta D9,15
Penta E10,12
TH018
TPOX8,10
vWA16,17

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Publications

PubMed=31882401; DOI=10.1158/0008-5472.CAN-19-2330; PMCID=PMC7029677
Johannes C. Melms, Sreeram Vallabhaneni, Caitlin Elizabeth Mills, Clarence Yapp, Jia-Yun Chen, Eugenio Morelli, Patricia Waszyk, Sushil Kumar, Derrick Deming, Nienke Moret, Steven Rodriguez ...Show all 24 authors... , Kartik Subramanian, Meri Rogava, Adam N.R. Cartwright, Adrienne Luoma, Shao-Lin Mei, Titus Josef Brinker, David M. Miller, Alexander Spektor, Dirk Schadendorf, Nicolo Riggi, Kai W. Wucherpfennig, Peter Karl Sorger, Benjamin Izar; Show fewer authors
Inhibition of haspin kinase promotes cell-intrinsic and extrinsic antitumor activity.
Cancer Res. 80:798-810(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A1VP
Cell_Model_Passport; SIDM01935
DepMap; ACH-002001
Encyclopedic resources Wikidata; Q105506031
Entry history
Entry creation12-Jan-2021
Last entry update19-Dec-2024
Version number10