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Cellosaurus JIL-2266 (CVCL_A1TT)

[Text version]
Cell line name JIL-2266
Synonyms JIL-O
Accession CVCL_A1TT
Resource Identification Initiative To cite this cell line use: JIL-2266 (RRID:CVCL_A1TT)
Comments Doubling time: ~39 hours (DOI=10.1530/endoabs.70.AEP83); 41 hours (PubMed=33830941).
Derived from site: In situ; Adrenal gland; UBERON=UBERON_0002369.
Sequence variations
  • Mutation; HGNC; HGNC:7527; MUTYH; Simple; p.Arg106Trp (c.316C>T) (p.Arg81Trp, c.241C>T); ClinVar=VCV000183896; Zygosity=Heterozygous; Note=Germline (PubMed=33830941).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu287Ter (c.859G>T); Zygosity=Hemizygous (DOI=10.1530/endoabs.70.AEP83; PubMed=33830941).
Disease Adrenal cortex carcinoma (NCIt: C9325)
Adrenocortical carcinoma (ORDO: Orphanet_1501)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 50Y
Category Cancer cell line
STR profile Source(s): PubMed=33830941

Markers:
AmelogeninX
CSF1PO12
D5S81811,13
D7S8209,12
D13S3179
D16S53913
TH018
TPOX12
vWA18

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Publications

DOI=10.1530/endoabs.70.AEP83
Landwehr L.-S., Jochen S., Herterich S., Appenzeller S., Fassnacht M., Kroiss M., Weigand I.
JIL-O: establishment of a new steroidogenic human adrenocortical carcinoma cell line.
Endocr. Abstr. 70:AEP83-AEP83(2020)

PubMed=33830941; DOI=10.1530/EJE-20-1423
Landwehr L.-S., Schreiner J., Appenzeller S., Kircher S., Herterich S., Sbiera S., Fassnacht M., Kroiss M., Weigand I.
A novel patient-derived cell line of adrenocortical carcinoma shows a pathogenic role of germline MUTYH mutation and high tumour mutational burden.
Eur. J. Endocrinol. 184:823-835(2021)

PubMed=35764904; DOI=10.1007/s12020-022-03112-w; PMCID=PMC9385758
Sigala S., Rossini E., Abate A., Tamburello M., Bornstein S.R., Hantel C.
An update on adrenocortical cell lines of human origin.
Endocrine 77:432-437(2022)

Cross-references
Encyclopedic resources Wikidata; Q105509737
Entry history
Entry creation12-Jan-2021
Last entry update19-Dec-2024
Version number6