ID   JIL-2266
AC   CVCL_A1TT
SY   JIL-O
DR   Wikidata; Q105509737
RX   DOI=10.1530/endoabs.70.AEP83;
RX   PubMed=33830941;
RX   PubMed=35764904;
CC   Doubling time: ~39 hours (DOI=10.1530/endoabs.70.AEP83); 41 hours (PubMed=33830941).
CC   Sequence variation: Mutation; HGNC; HGNC:7527; MUTYH; Simple; p.Arg106Trp (c.316C>T) (p.Arg81Trp, c.241C>T); ClinVar=VCV000183896; Zygosity=Heterozygous; Note=Germline (PubMed=33830941).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu287Ter (c.859G>T); Zygosity=Hemizygous (DOI=10.1530/endoabs.70.AEP83; PubMed=33830941).
CC   Derived from site: In situ; Adrenal gland; UBERON=UBERON_0002369.
ST   Source(s): PubMed=33830941
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 9
ST   D16S539: 13
ST   D5S818: 11,13
ST   D7S820: 9,12
ST   TH01: 8
ST   TPOX: 12
ST   vWA: 18
DI   NCIt; C9325; Adrenal cortex carcinoma
DI   ORDO; Orphanet_1501; Adrenocortical carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   50Y
CA   Cancer cell line
DT   Created: 12-01-21; Last updated: 19-12-24; Version: 6
//
RX   DOI=10.1530/endoabs.70.AEP83;
RA   Landwehr L.-S., Jochen S., Herterich S., Appenzeller S., Fassnacht M.,
RA   Kroiss M., Weigand I.;
RT   "JIL-O: establishment of a new steroidogenic human adrenocortical
RT   carcinoma cell line.";
RL   Endocr. Abstr. 70:AEP83-AEP83(2020).
//
RX   PubMed=33830941; DOI=10.1530/EJE-20-1423;
RA   Landwehr L.-S., Schreiner J., Appenzeller S., Kircher S., Herterich S.,
RA   Sbiera S., Fassnacht M., Kroiss M., Weigand I.;
RT   "A novel patient-derived cell line of adrenocortical carcinoma shows a
RT   pathogenic role of germline MUTYH mutation and high tumour mutational
RT   burden.";
RL   Eur. J. Endocrinol. 184:823-835(2021).
//
RX   PubMed=35764904; DOI=10.1007/s12020-022-03112-w; PMCID=PMC9385758;
RA   Sigala S., Rossini E., Abate A., Tamburello M., Bornstein S.R.,
RA   Hantel C.;
RT   "An update on adrenocortical cell lines of human origin.";
RL   Endocrine 77:432-437(2022).
//