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Cellosaurus Evsa-T GDC-0941-resistant clone 1 (CVCL_A1FL)

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Cell line name Evsa-T GDC-0941-resistant clone 1
Accession CVCL_A1FL
Resource Identification Initiative To cite this cell line use: Evsa-T GDC-0941-resistant clone 1 (RRID:CVCL_A1FL)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_65326; Pictrelisib (Pictilisib; GDC-0941).
Omics: Genomics; Whole exome sequencing.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:1748; CDH1; Simple; c.687+1_687+2delGT; ClinVar=VCV000483268; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8976; PIK3CB; Simple; p.Asp1067Tyr (c.3199G>T); Zygosity=Heterozygous; Note=Responsible for pictrelisib resistance (PubMed=26759240).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Thr319fs*1 (c.951_954delACTT) (p.VL317fs) (V317fs*3); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser241Cys (c.722C>G); ClinVar=VCV000177791; Zygosity=Homozygous (from parent cell line).
Disease Breast carcinoma (NCIt: C4872)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1207 (Evsa-T)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=26759240; DOI=10.1158/0008-5472.CAN-15-2201
Yoshito Nakanishi, Kimberly Walter, Jill M. Spoerke, Carol O'Brien, Ling Y. Huw, Garret M. Hampton, Mark R. Lackner;
Activating mutations in PIK3CB confer resistance to PI3K inhibition and define a novel oncogenic role for p110beta.
Cancer Res. 76:1193-1203(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A1FL
Encyclopedic resources Wikidata; Q102113801
Polymorphism and mutation databases Cosmic; 2787555
Entry history
Entry creation29-Oct-2020
Last entry update10-Apr-2025
Version number9