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Cellosaurus Evsa-T (CVCL_1207)

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Cell line name Evsa-T
Synonyms EVSA-T; EVSa-T; EVSA/T; Evsa T; EVSAT; EvsaT
Accession CVCL_1207
Resource Identification Initiative To cite this cell line use: Evsa-T (RRID:CVCL_1207)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: JWGray breast cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Doubling time: 25 hours (PubMed=9488600); ~50 hours (DSMZ=ACC-433).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:1748; CDH1; Simple; c.687+1_687+2delGT; ClinVar=VCV000483268; Zygosity=Homozygous (PubMed=19593635).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Thr319fs*1 (c.951_954delACTT) (p.VL317fs) (V317fs*3); Zygosity=Homozygous (PubMed=19593635).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser241Cys (c.722C>G); ClinVar=VCV000177791; Zygosity=Homozygous (PubMed=16541312; Cosmic-CLP=906862).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.86
Native American1.1
East Asian, North2.9
East Asian, South0
South Asian8.5
European, North19.45
European, South67.19
Disease Breast carcinoma (NCIt: C4872)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_A1FL (Evsa-T GDC-0941-resistant clone 1)
Originate from same individual CVCL_5G37 ! Evsa-E
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=906862; DSMZ=ACC-433; PubMed=25877200

Markers:
AmelogeninX
CSF1PO11,12
D2S133824
D3S135814,17
D5S81812,13
D7S82010,12
D8S117916
D13S31711,12 (Cosmic-CLP=906862; DSMZ=ACC-433)
12 (PubMed=25877200)
D16S5399
D18S5112,17
D19S43313
D21S1130,31.2
FGA21,24,25
Penta D12,14
Penta E12,16
TH016
TPOX8
vWA15,16

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Info; Synapse; JWGray panel; https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
Publications

PubMed=1000504
Marc E. Lippman, Gall Bolan, Karen Huff;
The effects of estrogens and antiestrogens on hormone-responsive human breast cancer in long-term tissue culture.
Cancer Res. 36:4595-4601(1976)

PubMed=1000505
Marc E. Lippman, Gall Bolan, Karen Huff;
The effects of glucocorticoids and progesterone on hormone-responsive human breast cancer in long-term tissue culture.
Cancer Res. 36:4602-4609(1976)

PubMed=212193
Linda W. Engel, Nathaniel A. Young;
Human breast carcinoma cells in continuous culture: a review.
Cancer Res. 38:4327-4339(1978)

PubMed=3702420; DOI=10.1016/0022-4731(86)90083-X
Nicole Devleeschouwer, Nicolas Olea-Serrano, Guy Leclercq, Nicole Legros, Jean-Claude Heuson;
Induction of progesterone receptor in an estrogen, progesterone receptor-negative breast cancer cell line.
J. Steroid Biochem. 24:365-368(1986)

PubMed=9570382; DOI=10.1016/S0304-3835(97)00285-1
Manuel Borras, Marc Lacroix, Nicole Legros, Guy Leclercq;
Estrogen receptor-negative/progesterone receptor-positive Evsa-T mammary tumor cells: a model for assessing the biological property of this peculiar phenotype of breast cancers.
Cancer Lett. 120:23-30(1997)

PubMed=9488600; DOI=10.1007/s002800050744
Jian-Guo Ma, Marc Maliepaard, Kees Nooter, Antonius W.M. Boersma, Jaap Verweij, Gerrit Stoter, Jan H.M. Schellens;
Synergistic cytotoxicity of cisplatin and topotecan or SN-38 in a panel of eight solid-tumor cell lines in vitro.
Cancer Chemother. Pharmacol. 41:307-316(1998)

PubMed=16142302; DOI=10.3892/ijo.27.4.881
Francoise de Longueville, Marc Lacroix, Anna-Maria Barbuto, Vincent Bertholet, Dominique Gallo, Denis Larsimont, Laurence Marcq, Nathalie Zammatteo, Sophie Boffe, Guy Leclercq, Jose Remacle;
Molecular characterization of breast cancer cell lines by a low-density microarray.
Int. J. Oncol. 27:881-892(2005)

PubMed=16397213; DOI=10.1158/0008-5472.CAN-05-2853
Fons Elstrodt, Antoinette Hollestelle, Jord H.A. Nagel, Michael Gorin, Marijke Wasielewski, Ans M.W. van den Ouweland, Sofia Diana Merajver, Stephen P. Ethier, Mieke Schutte;
BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants.
Cancer Res. 66:41-45(2006)

PubMed=16541312; DOI=10.1007/s10549-006-9186-z
Marijke Wasielewski, Fons Elstrodt, Jan G.M. Klijn, Els M.J.J. Berns, Mieke Schutte;
Thirteen new p53 gene mutants identified among 41 human breast cancer cell lines.
Breast Cancer Res. Treat. 99:97-101(2006)

PubMed=19593635; DOI=10.1007/s10549-009-0460-8
Antoinette Hollestelle, Jord H.A. Nagel, Marcel Smid, Suzanne Lam, Fons Elstrodt, Marijke Wasielewski, Ser Sue Ng, Pim J. French, Justine K. Peeters, Marieke J. Rozendaal, Muhammad Riaz ...Show all 26 authors... , Daphne G. Koopman, Timo L.M. ten Hagen, Bertie H.C.G.M. de Leeuw, Ellen C. Zwarthoff, Amina F.A.S. Teunisse, Peter J. van der Spek, Jan G.M. Klijn, Winand N.M. Dinjens, Stephen P. Ethier, Hans Cornelius Clevers, Aart G. Jochemsen, Michael A. den Bakker, John A. Foekens, John W.M. Martens, Mieke Schutte; Show fewer authors
Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines.
Breast Cancer Res. Treat. 121:53-64(2010)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=23601657; DOI=10.1186/bcr3415; PMCID=PMC3672661
Muhammad Riaz, Marijn T.M. van Jaarsveld, Antoinette Hollestelle, Wendy J.C. Prager-van der Smissen, Anouk A.J. Heine, Antonius W.M. Boersma, Jing-Jing Liu, Jean C.A. Helmijr, Bahar Ozturk, Marcel Smid, Erik A.C. Wiemer ...Show all 13 authors... , John A. Foekens, John W.M. Martens; Show fewer authors
miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs.
Breast Cancer Res. 15:R33.1-R33.17(2013)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110; PMCID=PMC3937590
Anneleen Daemen, Obi L. Griffith, Laura M. Heiser, Nicholas J. Wang, Oana M. Enache, Zachary Sanborn, Francois Pepin, Steffen Durinck, James E. Korkola, Malachi Griffith, Joe S. Hur ...Show all 27 authors... , Nam Huh, Jongsuk Chung, Leslie Cope, Mary Jo Fackler, Christopher Benedict Umbricht, Saraswati Sukumar, Pankaj Seth, Vikas P. Sukhatme, Lakshmi R. Jakkula, Yi-Ling Lu, Gordon B. Mills, Raymond J. Cho, Eric A. Collisson, Laura J. van 't Veer, Paul T. Spellman, Joe W. Gray; Show fewer authors
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26759240; DOI=10.1158/0008-5472.CAN-15-2201
Yoshito Nakanishi, Kimberly Walter, Jill M. Spoerke, Carol O'Brien, Ling Y. Huw, Garret M. Hampton, Mark R. Lackner;
Activating mutations in PIK3CB confer resistance to PI3K inhibition and define a novel oncogenic role for p110beta.
Cancer Res. 76:1193-1203(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-433
Cell line databases/resources CLO; CLO_0002955
cancercelllines; CVCL_1207
Cell_Model_Passport; SIDM01042
Cosmic-CLP; 906862
DepMap; ACH-001065
DSMZCellDive; ACC-433
LINCS_LDP; LCL-1313
TOKU-E; 4049
Biological sample resources BioSample; SAMN03472910
BioSample; SAMN03473598
BioSample; SAMN10988228
CRISP screens repositories BioGRID_ORCS_Cell_line; 885
Chemistry resources ChEMBL-Cells; CHEMBL3307361
ChEMBL-Targets; CHEMBL614295
GDSC; 906862
PharmacoDB; EVSAT_349_2019
PubChem_Cell_line; CVCL_1207
Encyclopedic resources Wikidata; Q54832986
Experimental variables resources EFO; EFO_0006574
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-3610
GEO; GSM274650
GEO; GSM344366
GEO; GSM344416
GEO; GSM421866
GEO; GSM783964
GEO; GSM843500
GEO; GSM843501
GEO; GSM847317
GEO; GSM847471
GEO; GSM1172953
GEO; GSM1374477
GEO; GSM1661978
GEO; GSM1669780
Polymorphism and mutation databases Cosmic; 906862
Cosmic; 944298
Cosmic; 997931
Cosmic; 1046926
Cosmic; 1287906
Cosmic; 1289388
Cosmic; 2165020
Cosmic; 2750518
Cosmic; 2787554
IARC_TP53; 24357
Progenetix; CVCL_1207
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number44