Cellosaurus cell line ABC-17 (CVCL

Cellosaurus ABC-17 (CVCL_A1EG)

Cross-references
Cell line name	ABC-17
Accession	CVCL_A1EG
Resource Identification Initiative	To cite this cell line use: ABC-17 (RRID:CVCL_A1EG)
Comments	Population: Japanese. Characteristics: Established from a xenograft produced by subcutaneous injection of tumor cells into NOG (NOD/Shi-scid, IL-2RgammaKO Jic) mice. Characteristics: Resistant to alectinib and crizotinib. Omics: Transcriptomics; RNAseq. Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations	Gene fusion; HGNC; HGNC:427; ALK + HGNC; HGNC:1316; EML4; Name(s)=EML4-ALK (PubMed=31374369). Mutation; HGNC; HGNC:427; ALK; Simple; p.Gly1202Arg (c.3604G>A); ClinVar=VCV000376134; Zygosity=Unspecified (PubMed=31374369).
Disease	Lung adenocarcinoma (NCIt: C3512)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_A1EF ! ABC-14
Sex of cell	Male
Age at sampling	51Y
Category	Cancer cell line
Publications	PubMed=31374369; DOI=10.1016/j.jtho.2019.07.017 Go Makimoto, Kadoaki Ohashi, Shuta Tomida, Kazuya Nishii, Takehiro Matsubara, Hiroe Kayatani, Hisao Higo, Kiichiro Ninomiya, Akiko Sato, Hiromi Watanabe, Hirohisa Kano ...Show all 21 authors... , Takashi Ninomiya, Toshio Kubo, Kammei Rai, Eiki Ichihara, Katsuyuki Hotta, Masahiro Tabata, Shinichi Toyooka, Minoru Takata, Yoshinobu Maeda, Katsuyuki Kiura; Show fewer authors Rapid acquisition of alectinib resistance in ALK-positive lung cancer with high tumor mutation burden. J. Thorac. Oncol. 14:2009-2018(2019)
Cell line databases/resources	cancercelllines; CVCL_A1EG
Encyclopedic resources	Wikidata; Q102113499
Polymorphism and mutation databases	Cosmic; 2843084
Entry history
Entry creation	29-Oct-2020
Last entry update	10-Apr-2025
Version number	8