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Cellosaurus VCaP AR-V7/pHag (CVCL_A1BP)

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Cell line name VCaP AR-V7/pHag
Synonyms VCaPAR-V7/pHag
Accession CVCL_A1BP
Resource Identification Initiative To cite this cell line use: VCaP AR-V7/pHag (RRID:CVCL_A1BP)
Comments Population: Caucasian.
Characteristics: Inducibly expresses AR variant 7 (ARv7).
Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (from parent cell line).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:644; AR (Note=Isoform ARv7).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Bone, vertebra; UBERON=UBERON_0002412.
Sequence variations
  • Gene fusion; HGNC; HGNC:3446; ERG + HGNC; HGNC:11876; TMPRSS2; Name(s)=TMPRSS2-ERG (from parent cell line).
  • Mutation; HGNC; HGNC:7127; MLH1; Simple; p.Ile219Val (c.655A>G); ClinVar=VCV000036557; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2235 (VCaP)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
Publications

PubMed=25008967; DOI=10.1016/j.biocel.2014.06.013; PMCID=PMC4160387
William C. Krause, Ayesha A. Shafi, Manjula Nakka, Nancy L. Weigel;
Androgen receptor and its splice variant, AR-V7, differentially regulate FOXA1 sensitive genes in LNCaP prostate cancer cells.
Int. J. Biochem. Cell Biol. 54:49-59(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A1BP
Encyclopedic resources Wikidata; Q102115093
Entry history
Entry creation29-Oct-2020
Last entry update14-Aug-2025
Version number12