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Cellosaurus BON1-MEN1-KO (CVCL_A1AU)

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Cell line name BON1-MEN1-KO
Synonyms MEN1-KO-BON1
Accession CVCL_A1AU
Resource Identification Initiative To cite this cell line use: BON1-MEN1-KO (RRID:CVCL_A1AU)
Comments Doubling time: 36 +- 0.48 hours (PubMed=32884006).
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:7010; MEN1.
Omics: Proteomics; Quantitative.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Glu1317Gln (c.3949G>C); ClinVar=VCV000000829; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Cys1960Tyr (c.5879G>A); ClinVar=VCV000038003; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg342Ter (c.1024C>T); ClinVar=VCV000182970; Zygosity=Homozygous (from parent cell line).
Disease Pancreatic serotonin-producing neuroendocrine tumor (NCIt: C4446)
Serotonin-producing neuroendocrine tumor of pancreas (ORDO: Orphanet_506090)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3985 (BON-1)
Sex of cell Male
Age at sampling 28Y
Category Cancer cell line
Publications

PubMed=32884006; DOI=10.1038/s41598-020-71516-7; PMCID=PMC7471701
Azita Monazzam, Su-Chen Li, Hanna Wargelius, Masoud Razmara, Duska Bajic, Jia Mi, Jonas Bergquist, Joakim Crona, Britt Skogseid;
Generation and characterization of CRISPR/Cas9-mediated MEN1 knockout BON1 cells: a human pancreatic neuroendocrine cell line.
Sci. Rep. 10:14572.1-14572.10(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A1AU
Encyclopedic resources Wikidata; Q102113642
Entry history
Entry creation29-Oct-2020
Last entry update10-Apr-2025
Version number9