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Cellosaurus BON-1 (CVCL_3985)

[Text version]
Cell line name BON-1
Synonyms Bon-1; BON1; BON
Accession CVCL_3985
Secondary accession CVCL_B390
Resource Identification Initiative To cite this cell line use: BON-1 (RRID:CVCL_3985)
Comments Doubling time: 1.5 +- 0.4 days (PubMed=29330294); 46 +- 0.72 hours (PubMed=32884006).
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Quantitative.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
Disease Pancreatic serotonin-producing neuroendocrine tumor (NCIt: C4446)
Serotonin-producing neuroendocrine tumor of pancreas (ORDO: Orphanet_506090)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_WV97 (BON1 RR1)CVCL_WV98 (BON1 RR2)CVCL_A1AU (BON1-MEN1-KO)
Sex of cell Male
Age at sampling 28Y
Category Cancer cell line
STR profile Source(s): PubMed=29444910

Markers:
AmelogeninX,Y
CSF1PO10,11
D5S8189,12
D7S8209
D13S31711,12
D16S53910,11
D21S1128,33.2
TH018
TPOX9
vWA18,19

Run an STR similarity search on this cell line
Web pages Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=BON
Publications

PubMed=1712329; DOI=10.5555/uri:pii:0016508591900045
B. Mark Evers, Courtney M. Townsend Jr., James Robert Upp Jr., Erick Allen, Stephen C. Hurlbut, Sun-Whe Kim, Sirinivasan Rajaraman, Pomila Singh, Jean-Claude Reubi, James C. Thompson;
Establishment and characterization of a human carcinoid in nude mice and effect of various agents on tumor growth.
Gastroenterology 101:303-311(1991)

PubMed=7978888; DOI=10.1111/j.1749-6632.1994.tb17289.x
B. Mark Evers, Jin Ishizuka, Courtney M. Townsend Jr., James C. Thompson;
The human carcinoid cell line, BON. A model system for the study of carcinoid tumors.
Ann. N. Y. Acad. Sci. 733:393-406(1994)

PubMed=8108375; DOI=10.1097/00006676-199401000-00013
Dilipkumar Parekh, Jin Ishizuka, Courtney M. Townsend Jr., Bernard Haber, R. Daniel Beauchamp, George Karp, Sun-Whe Kim, Sirinivasan Rajaraman, George H. Greeley Jr., James C. Thompson;
Characterization of a human pancreatic carcinoid in vitro: morphology, amine and peptide storage, and secretion.
Pancreas 9:83-90(1994)

PubMed=19295186; DOI=10.1159/000209330
Zakiya-Luna Siddique, Ignat Drozdov, Jared Floch, Bjorn Inge Gustafsson, Kamilla Stunes, Roswitha Pfragner, Mark Kidd, Irvin M. Modlin;
KRJ-I and BON cell lines: defining an appropriate enterochromaffin cell neuroendocrine tumor model.
Neuroendocrinology 89:458-470(2009)

PubMed=22538498; DOI=10.1159/000338793
Simona Grozinsky-Glasberg, Ilan Shimon, Hadara Rubinfeld;
The role of cell lines in the study of neuroendocrine tumors.
Neuroendocrinology 96:173-187(2012)

PubMed=22929519; DOI=10.3791/4218; PMCID=PMC3486771
Chung Wong, Evan Vosburgh, Arnold Jay Levine, Lei Cong, Eugenia Y. Xu;
Human neuroendocrine tumor cell lines as a three-dimensional model for the study of human neuroendocrine tumor therapy.
J. Vis. Exp. 66:e4218.1-e4218.7(2012)

PubMed=25612765; DOI=10.1530/JME-14-0304
Timon Vandamme, Marc Peeters, Fadime Dogan, Patrick Pauwels, Elvire Van Assche, Matthias Beyens, Geert Mortier, Geert Vandeweyer, Wouter de Herder, Guy Van Camp, Leo J. Hofland, Ken Op de Beeck;
Whole-exome characterization of pancreatic neuroendocrine tumor cell lines BON-1 and QGP-1.
J. Mol. Endocrinol. 54:137-147(2015)

PubMed=26087898; DOI=10.1016/j.cancergen.2015.04.002
Ganesh K. Boora, Rahul Kanwar, Amit A. Kulkarni, Josef Pleticha, Matthew Ames, Gary P. Schroth, Andreas S. Beutler, Michaela S. Banck;
Exome-level comparison of primary well-differentiated neuroendocrine tumors and their cell lines.
Cancer Genet. 208:374-381(2015)

PubMed=29330294; DOI=10.1158/1541-7786.MCR-17-0163
Daniel Benten, Yasmin Behrang, Ludmilla Unrau, Victoria Weissmann, Gerrit Wolters-Eisfeld, Susanne Burdak-Rothkamm, Felix R. Stahl, Martin Anlauf, Patricia Grabowski, Markus Mobs, Jan Dieckhoff ...Show all 19 authors... , Bence Sipos, Martina Fahl, Corinna Eggers, Daniel Perez, Maximilian Bockhorn, Jakob Robert Izbicki, Ansgar W. Lohse, Jorg Schrader; Show fewer authors
Establishment of the first well-differentiated human pancreatic neuroendocrine tumor model.
Mol. Cancer Res. 16:496-507(2018)

PubMed=29444910; DOI=10.1530/ERC-17-0445; PMCID=PMC5827037
Tobias Hofving, Yvonne Arvidsson, Bilal Almobarak, Linda Inge, Roswitha Pfragner, Marta Persson, Goran Stenman, Erik Kristiansson, Viktor Johanson, Ola Nilsson;
The neuroendocrine phenotype, genomic profile and therapeutic sensitivity of GEPNET cell lines.
Endocr. Relat. Cancer 25:367-380(2018)

PubMed=29895527; DOI=10.1530/ERC-18-0159; PMCID=PMC7439002
Elke Tatjana Aristizabal Prada, Gerald Spottl, Julian Maurer, Michael Lauseker, Eva Jolanthe Koziolek, Jorg Schrader, Ashley Grossman, Karel Pacak, Felix Beuschlein, Christoph Joseph Auernhammer, Svenja Nolting;
The role of GSK3 and its reversal with GSK3 antagonism in everolimus resistance.
Endocr. Relat. Cancer 25:893-908(2018)

CLPUB00598
Yasmin Behrang;
Establishment and characterization of a new human, highly differentiated and functionally active tumor model of a pancreatic neuroendocrine tumor.
Thesis MD (2020); University of Hamburg; Hamburg; Germany

PubMed=32884006; DOI=10.1038/s41598-020-71516-7; PMCID=PMC7471701
Azita Monazzam, Su-Chen Li, Hanna Wargelius, Masoud Razmara, Duska Bajic, Jia Mi, Jonas Bergquist, Joakim Crona, Britt Skogseid;
Generation and characterization of CRISPR/Cas9-mediated MEN1 knockout BON1 cells: a human pancreatic neuroendocrine cell line.
Sci. Rep. 10:14572.1-14572.10(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_3985
Anatomy/cell type resources BTO; BTO_0003856
Encyclopedic resources Wikidata; Q54797946
Experimental variables resources EFO; EFO_0022643
Polymorphism and mutation databases Cosmic; 721017
Cosmic; 1620107
Cosmic; 1879411
Cosmic; 2433550
Cosmic; 2530675
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number20