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Cellosaurus Ma-Mel-08a (CVCL_A121)

[Text version]
Cell line name Ma-Mel-08a
Synonyms Ma-Mel-8a; MaMel-08a; MaMel08a
Accession CVCL_A121
Resource Identification Initiative To cite this cell line use: Ma-Mel-08a (RRID:CVCL_A121)
Comments Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Hypodermis; UBERON=UBERON_0002072.
Derived from site: Metastatic; Skin; UBERON=UBERON_0002097.
Sequence variations
Disease Cutaneous nodular melanoma (NCIt: C4225)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_A122 ! Ma-Mel-08b
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): ECACC=13012434; ESTDAB=ESTDAB-105

Markers:
AmelogeninX,Y
CSF1PO11,12
D3S135814,15
D5S81812,13
D7S82010
D13S31712
D16S5399,13
FGA21
TH019.3
TPOX8
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=17311103; DOI=10.1371/journal.pone.0000236; PMCID=PMC1794595
Selma Ugurel, Ranjit K. Thirumaran, Sandra Bloethner, Andreas Gast, Antje Sucker, Jan Mueller-Berghaus, Werner Rittgen, Kari Hemminki, Jurgen C. Becker, Rajiv Kumar, Dirk Schadendorf;
B-RAF and N-RAS mutations are preserved during short time in vitro propagation and differentially impact prognosis.
PLoS ONE 2:e236.1-e236.13(2007)

PubMed=20544847; DOI=10.1002/gcc.20785
Andreas Gast, Dominique Scherer, Bo-Wang Chen, Sandra Bloethner, Stephanie Melchert, Antje Sucker, Kari Hemminki, Dirk Schadendorf, Rajiv Kumar;
Somatic alterations in the melanoma genome: a high-resolution array-based comparative genomic hybridization study.
Genes Chromosomes Cancer 49:733-745(2010)

PubMed=23348503; DOI=10.1126/science.1230062
Susanne Horn, Adina Figl, P. Sivaramakrishna Rachakonda, Christine Fischer, Antje Sucker, Andreas Gast, Stephanie Kadel, Iris Moll, Eduardo Nagore, Kari Hemminki, Dirk Schadendorf, Rajiv Kumar;
TERT promoter mutations in familial and sporadic melanoma.
Science 339:959-961(2013)

PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006
Christina Dahl, Claus Christensen, Goran Jonsson, Anders Lorentzen, Mette Louise Skjodt, Ake Borg, Graham Pawelec, Per Guldberg;
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Mol. Cancer Res. 11:1166-1178(2013)

PubMed=26909863; DOI=10.18632/oncotarget.7503; PMCID=PMC4941330
Hua-Ping Xie, P. Sivaramakrishna Rachakonda, Barbara Heidenreich, Eduardo Nagore, Antje Sucker, Kari Hemminki, Dirk Schadendorf, Rajiv Kumar;
Mapping of deletion breakpoints at the CDKN2A locus in melanoma: detection of MTAP-ANRIL fusion transcripts.
Oncotarget 7:16490-16504(2016)

Cross-references
Cell line collections (Providers) ECACC; 13012434
Cell line databases/resources cancercelllines; CVCL_A121
ESTDAB; ESTDAB-105
Encyclopedic resources Wikidata; Q54903730
Gene expression databases GEO; GSM436989
Polymorphism and mutation databases Cosmic; 1467738
Cosmic; 1846566
Cosmic; 2163818
Cosmic; 2686330
Progenetix; CVCL_A121
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number22