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Cellosaurus MDA-MB-231bo (CVCL_A0YX)

[Text version]
Cell line name MDA-MB-231bo
Synonyms MDA-231BO
Accession CVCL_A0YX
Resource Identification Initiative To cite this cell line use: MDA-MB-231bo (RRID:CVCL_A0YX)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Characteristics: Metastatic to bone. Established after injection of the parent cell line in the left ventricle of the heart of female nude mice and retrieving the bone metastatic cells and repeating this procedure 11 times.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=11499871; DOI=10.1359/jbmr.2001.16.8.1486
Yoneda T., Williams P.J., Hiraga T., Niewolna M., Nishimura R.
A bone-seeking clone exhibits different biological properties from the MDA-MB-231 parental human breast cancer cells and a brain-seeking clone in vivo and in vitro.
J. Bone Miner. Res. 16:1486-1495(2001)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A0YX
Encyclopedic resources Wikidata; Q108820877
Entry history
Entry creation23-Sep-2021
Last entry update05-Oct-2023
Version number6