ID   MDA-MB-231bo
AC   CVCL_A0YX
SY   MDA-231BO
DR   cancercelllines; CVCL_A0YX
DR   Wikidata; Q108820877
RX   PubMed=11499871;
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Population: Caucasian.
CC   Characteristics: Metastatic to bone. Established after injection of the parent cell line in the left ventricle of the heart of female nude mice and retrieving the bone metastatic cells and repeating this procedure 11 times.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C5214; Breast adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0062 ! MDA-MB-231
SX   Female
AG   51Y
CA   Cancer cell line
DT   Created: 23-09-21; Last updated: 05-10-23; Version: 6
//
RX   PubMed=11499871; DOI=10.1359/jbmr.2001.16.8.1486;
RA   Yoneda T., Williams P.J., Hiraga T., Niewolna M., Nishimura R.;
RT   "A bone-seeking clone exhibits different biological properties from
RT   the MDA-MB-231 parental human breast cancer cells and a brain-seeking
RT   clone in vivo and in vitro.";
RL   J. Bone Miner. Res. 16:1486-1495(2001).
//