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Cellosaurus VCaP-CR (CVCL_A0BX)

[Text version]
Cell line name VCaP-CR
Accession CVCL_A0BX
Resource Identification Initiative To cite this cell line use: VCaP-CR (RRID:CVCL_A0BX)
Comments Population: Caucasian.
Characteristics: Derived after a passage of the parent cell line in castrated nude mice.
Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (from parent cell line).
Doubling time: ~60 hours (PubMed=34402095).
Omics: Proteomics.
Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Bone, vertebra; UBERON=UBERON_0002412.
Sequence variations
  • Gene fusion; HGNC; HGNC:3446; ERG + HGNC; HGNC:11876; TMPRSS2; Name(s)=TMPRSS2-ERG (from parent cell line).
  • Mutation; HGNC; HGNC:7127; MLH1; Simple; p.Ile219Val (c.655A>G); ClinVar=VCV000036557; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2235 (VCaP)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
Publications

PubMed=34402095; DOI=10.1002/pros.24210; PMCID=PMC8460612
Michael C. Haffner, Akshay Bhamidipati, Harrison K. Tsai, David M. Esopi, Ajay M. Vaghasia, Jin-Yih Low, Radhika A. Patel, Gunes Guner, Minh-Tam Pham, Nicole Castagna, Jessica L. Hicks ...Show all 17 authors... , Nicolas Wyhs, Rudolf Aebersold, Angelo M. De Marzo, William George Nelson, Tian-Nan Guo, Srinivasan Yegnasubramanian; Show fewer authors
Phenotypic characterization of two novel cell line models of castration-resistant prostate cancer.
Prostate 81:1159-1171(2021)

PubMed=38892296; DOI=10.3390/ijms25116111; PMCID=PMC11172770
Erica L. Beatson, Emily N. Risdon, Giulia C. Napoli, Douglas K. Price, Cindy H. Chau, William Douglas Figg Sr.;
Genomic characterization of preclinical prostate cancer cell line models.
Int. J. Mol. Sci. 25:6111.1-6111.19(2024)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A0BX
Encyclopedic resources Wikidata; Q108821488
Gene expression databases GEO; GSM5402197
Entry history
Entry creation23-Sep-2021
Last entry update10-Apr-2025
Version number9